Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice
| العنوان: | Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice |
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| المؤلفون: | Megumi Ikegami, Akane Sakai, Misa Kai, Junzo Kamei, Hiroko Ikeda, Yuki Nakanishi, Shun-suke Hayashi |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 2, p e0171819 (2017) |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Peptide Hormones, Cancer Treatment, lcsh:Medicine, Pharmacology, Pathology and Laboratory Medicine, Biochemistry, Nervous System, Mice, 0302 clinical medicine, Medicine and Health Sciences, Phosphorylation, lcsh:Science, Chemotherapeutic Agents, Mice, Inbred ICR, Multidisciplinary, NF-kappa B, Peripheral Nervous System Diseases, Drugs, Animal Models, Receptor antagonist, Ghrelin, Neuroprotective Agents, medicine.anatomical_structure, Spinal Cord, Neurology, Experimental Organism Systems, Oncology, Hyperalgesia, Neuropathic pain, Oncology Agents, Sciatic nerve, Anatomy, medicine.symptom, Signal Transduction, Research Article, Paclitaxel, medicine.drug_class, Pain, Mouse Models, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, Model Organisms, Diagnostic Medicine, medicine, Animals, Pain Management, Peripheral Neuropathy, Neuropathic Pain, business.industry, lcsh:R, Biology and Life Sciences, Spinal cord, NFKB1, medicine.disease, Hormones, Neuropathy, Neuroanatomy, 030104 developmental biology, Peripheral neuropathy, Neuralgia, lcsh:Q, business, 030217 neurology & neurosurgery, Drugs, Chinese Herbal, Neuroscience |
| الوصف: | Peripheral neuropathy is the major side effect caused by paclitaxel, a microtubule-binding antineoplastic drug. Paclitaxel-induced peripheral neuropathy causes a long-term negative impact on the patient's quality of life. However, the mechanism underlying paclitaxel-induced peripheral neuropathy is still unknown, and there is no established treatment. Ghrelin is known to attenuate thermal hyperalgesia and mechanical allodynia in chronic constriction injury of the sciatic nerve, and inhibit the activation of nuclear factor kappa B (NFκB) in the spinal dorsal horn. Rikkunshito (RKT), a kampo medicine, increases the secretion of ghrelin in rodents and humans. Thus, RKT may attenuate paclitaxel-induced peripheral neuropathy by inhibiting phosphorylated NFκB (pNFκB) in the spinal cord. We found that paclitaxel dose-dependently induced mechanical hyperalgesia in mice. Paclitaxel increased the protein levels of spinal pNFκB, but not those of spinal NFκB. NFκB inhibitor attenuated paclitaxel-induced mechanical hyperalgesia suggesting that the activation of NFκB mediates paclitaxel-induced hyperalgesia. RKT dose-dependently attenuated paclitaxel-induced mechanical hyperalgesia. Ghrelin receptor antagonist reversed the RKT-induced attenuation of paclitaxel-induced mechanical hyperalgesia. RKT inhibited the paclitaxel-induced increase in the protein levels of spinal pNFκB. Taken together, the present study indicates that RKT exerts an antihyperalgesic effect in paclitaxel-induced neuropathic pain by suppressing the activation of spinal NFκB. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97b38bfd8c53b46172a4ea2c2ca0baeTest https://doi.org/10.1371/journal.pone.0171819Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f97b38bfd8c53b46172a4ea2c2ca0bae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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