Armadillo Motifs Involved in Vesicular Transport
| العنوان: | Armadillo Motifs Involved in Vesicular Transport |
|---|---|
| المؤلفون: | Udo Heinemann, Harald Striegl, Miguel A. Andrade-Navarro |
| المصدر: | PLoS ONE PLoS ONE, Vol 5, Iss 2, p e8991 (2010) |
| بيانات النشر: | Public Library of Science (PLoS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Models, Molecular, Repetitive Sequences, Amino Acid, Cancer Research, Subfamily, Amino Acid Motifs, Molecular Sequence Data, Vesicular Transport Proteins, lcsh:Medicine, Computational Biology/Macromolecular Structure Analysis, Sequence alignment, Computational biology, Biology, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Computational Biology/Protein Homology Detection, Protein structure, biology.animal, Humans, Amino Acid Sequence, lcsh:Science, Transport Vesicles, Armadillo Domain Proteins, Genetics, Multidisciplinary, Sequence Homology, Amino Acid, lcsh:R, Computational Biology, Golgi Matrix Proteins, Computational Biology/Macromolecular Sequence Analysis, Biological Transport, Protein Structure, Tertiary, Vesicular transport protein, Biochemistry/Bioinformatics, Armadillo repeats, Armadillo, lcsh:Q, Technology Platforms, Protein Multimerization, Sequence motif, Research Article |
| الوصف: | Armadillo (ARM) repeat proteins function in various cellular processes including vesicular transport and membrane tethering. They contain an imperfect repeating sequence motif that forms a conserved three-dimensional structure. Recently, structural and functional insight into tethering mediated by the ARM-repeat protein p115 has been provided. Here we describe the p115 ARM-motifs for reasons of clarity and nomenclature and show that both sequence and structure are highly conserved among ARM-repeat proteins. We argue that there is no need to invoke repeat types other than ARM repeats for a proper description of the structure of the p115 globular head region. Additionally, we propose to define a new subfamily of ARM-like proteins and show lack of evidence that the ARM motifs found in p115 are present in other long coiled-coil tethering factors of the golgin family. |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d19db25013847d0dc21ea4b66a137bTest https://doi.org/10.1371/journal.pone.0008991Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....65d19db25013847d0dc21ea4b66a137b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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