نتائج البحث - "egfr inhibitors"

1

EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

المؤلفون: Carlos M. Luque, Jose F. de Celis, Jennifer Soler Beatty, Cristina Molnar, María D. Martín-Bermudo

المساهمون: Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Genetics
PLoS Genetics, Vol 17, Iss 8, p e1009738 (2021)

مصطلحات موضوعية: Cell signaling, Cancer Research, Carcinogenesis, Protein domains, Gene Expression, QH426-470, Signal transduction, medicine.disease_cause, Biochemistry, Morphogenesis, Medicine and Health Sciences, Drosophila Proteins, Phosphorylation, Genetics (clinical), EGFR inhibitors, Staining, Drosophila Melanogaster, Cell Cycle, Eukaryota, Cell Staining, Signal transducing adaptor protein, Animal Models, SH2 domains, Insects, ErbB Receptors, Gene Expression Regulation, Neoplastic, Phenotypes, Imaginal disc, Imaginal Discs, Experimental Organism Systems, Oncology, Drosophila, EGFR signaling, Research Article, Cell biology, Arthropoda, Notch signaling pathway, Biology, Research and Analysis Methods, Model Organisms, Downregulation and upregulation, Genetics, medicine, Animals, Receptors, Invertebrate Peptide, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Adaptor Proteins, Signal Transducing, Cell Proliferation, Cell growth, Organisms, Biology and Life Sciences, Cancers and Neoplasms, Proteins, Invertebrates, Genes, ras, Specimen Preparation and Treatment, Animal Studies, ras Proteins, Cancer research, Zoology, Entomology, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df37afd686fc5696e977c7c4677c296Test
https://doi.org/10.1371/journal.pgen.1009738Test

2

EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer

المؤلفون: Shawn J. Rice, Xin Liu, Hong Gang Wang, Chandra P. Belani

المصدر: PLoS ONE, Vol 14, Iss 5, p e0217657 (2019)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Cell signaling, medicine.medical_treatment, Protein Expression, Cancer Treatment, Apoptosis, Signal transduction, Lung and Intrathoracic Tumors, Targeted therapy, 0302 clinical medicine, Spectrum Analysis Techniques, Carcinoma, Non-Small-Cell Lung, Medicine and Health Sciences, Medicine, Phosphorylation, EGFR inhibitors, Multidisciplinary, medicine.diagnostic_test, Cell Death, Pharmaceutics, Flow Cytometry, ErbB Receptors, Oncogene Protein v-akt, Oncology, Proto-Oncogene Proteins c-bcl-2, Cell Processes, Spectrophotometry, 030220 oncology & carcinogenesis, Cytophotometry, EGFR signaling, Research Article, Cell Survival, Science, bcl-X Protein, Antineoplastic Agents, Research and Analysis Methods, Flow cytometry, 03 medical and health sciences, Drug Therapy, Cell Line, Tumor, Carcinoma, Gene Expression and Vector Techniques, Humans, Pyrroles, Lung cancer, Molecular Biology Techniques, Molecular Biology, Molecular Biology Assays and Analysis Techniques, business.industry, Cancer, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, medicine.disease, Non-Small Cell Lung Cancer, 030104 developmental biology, Cell culture, Drug Resistance, Neoplasm, Mutation, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbae5ae9ec604f10f10c3e5280d19d5Test
https://doaj.org/article/a7ad9fd966d24fb9bb72eeadce9a3546Test

3

Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab

المؤلفون: Chuyang Han, Guang Li, Chaonan Sun, Qiao Qiao, Miao Zhang, Ning Han, Yuanjun Jiang

المصدر: PLoS ONE, Vol 12, Iss 12, p e0188932 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, DNA Repair, medicine.medical_treatment, Protein Expression, Cancer Treatment, Cetuximab, lcsh:Medicine, Apoptosis, Endoplasmic Reticulum, Radiation Tolerance, Biochemistry, 0302 clinical medicine, Medicine and Health Sciences, Small interfering RNAs, lcsh:Science, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, EGFR inhibitors, Multidisciplinary, Secretory Pathway, Cell Death, Endoplasmic Reticulum Stress, ErbB Receptors, Nucleic acids, Oropharyngeal Neoplasms, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Cellular Structures and Organelles, medicine.drug, Signal Transduction, Research Article, Clinical Oncology, Autophagic Cell Death, Radiation Therapy, Protein Serine-Threonine Kinases, Research and Analysis Methods, Carcinomas, 03 medical and health sciences, Radioresistance, Cell Line, Tumor, Endoribonucleases, medicine, Carcinoma, Autophagy, Genetics, Gene Expression and Vector Techniques, Humans, Radiosensitivity, Molecular Biology Techniques, Non-coding RNA, Molecular Biology, neoplasms, Molecular Biology Assays and Analysis Techniques, Biology and life sciences, business.industry, lcsh:R, Cancers and Neoplasms, DNA, Cell Biology, medicine.disease, digestive system diseases, Activating Transcription Factor 6, Gene regulation, Radiation therapy, 030104 developmental biology, Oropharyngeal Carcinoma, Cancer research, RNA, lcsh:Q, Gene expression, Clinical Medicine, business, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363755df7543e9bd3b2d2046d5b89d84Test
http://europepmc.org/articles/PMC5726659?pdf=renderTest

4

Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients

المؤلفون: Hiroshi Haeno, Franziska Michor, Shayna Stein, Rui Zhao, Igor Vivanco

المصدر: PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 1, p e1005924 (2018)

مصطلحات موضوعية: Central Nervous System, 0301 basic medicine, Cell, Cancer Treatment, Toxicology, Pathology and Laboratory Medicine, Nervous System, Tyrosine-kinase inhibitor, 0302 clinical medicine, Medicine and Health Sciences, Epidermal growth factor receptor, Biology (General), EGFR inhibitors, Ecology, biology, Pharmaceutics, Brain Neoplasms, 3. Good health, ErbB Receptors, Cell Motility, medicine.anatomical_structure, Oncology, Computational Theory and Mathematics, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Modeling and Simulation, Anatomy, Research Article, medicine.drug, Maximum Tolerated Dose, QH301-705.5, Death Rates, medicine.drug_class, Antineoplastic Agents, Lapatinib, Models, Biological, Drug Administration Schedule, 03 medical and health sciences, Cellular and Molecular Neuroscience, Dose Prediction Methods, Drug Therapy, Population Metrics, In vivo, Cell Line, Tumor, Genetics, medicine, Humans, Pharmacokinetics, Dosing, Protein Kinase Inhibitors, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Pharmacology, Toxicity, Population Biology, business.industry, Biology and Life Sciences, Computational Biology, Cancer, Cell Biology, medicine.disease, Logistic Models, 030104 developmental biology, Mutation, Quinazolines, Cancer research, biology.protein, Glioblastoma, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e081879cd3e70838985421d5e5325eTest
https://doi.org/10.1371/journal.pcbi.1005924Test

5

MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition

المؤلفون: Richard W J Lee, Elena Ortiz-Zapater, George Santis, Tony Ng, Frank McCaughan, Michael J. Neat, Gilbert O. Fruhwirth, Gregory Weitsman, Peter J. Parker, W. Owen, Robert G Dunn

المساهمون: McCaughan, Frank [0000-0002-8012-7524], Apollo - University of Cambridge Repository

المصدر: Ortiz-Zapater, E, Lee, R W, Owen, W, Weitsman, G, Fruhwirth, G, Dunn, R G, Neat, M J, McCaughan, F, Parker, P, Ng, T & Santis, G 2017, ' MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition ', PLoS ONE, vol. 12, no. 1, pp. e0170798 . https://doi.org/10.1371/journal.pone.0170798Test
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170798 (2017)

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Kinase Inhibitors, Cancer Treatment, lcsh:Medicine, Physical Chemistry, Biochemistry, Fluorophotometry, T790M, Spectrum Analysis Techniques, 0302 clinical medicine, Fluorescence Resonance Energy Transfer, Medicine and Health Sciences, Phosphorylation, Enzyme Inhibitors, lcsh:Science, Extracellular Signal-Regulated MAP Kinases, EGFR inhibitors, Staining, Mice, Inbred BALB C, Multidisciplinary, Fluorescent in Situ Hybridization, Physics, Cell Staining, Proto-Oncogene Proteins c-met, Precipitation Techniques, ErbB Receptors, Chemistry, Oncology, Spectrophotometry, 030220 oncology & carcinogenesis, Physical Sciences, Erlotinib, Dimerization, Protein Binding, Research Article, medicine.drug, Chemical physics, Mice, Nude, Molecular Probe Techniques, Adenocarcinoma of Lung, Adenocarcinoma, Biology, Research and Analysis Methods, 03 medical and health sciences, Gefitinib, Growth factor receptor, Cell Line, Tumor, medicine, Animals, Humans, Immunoprecipitation, Molecular Biology Techniques, Lung cancer, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Cell growth, lcsh:R, Reproducibility of Results, Biology and Life Sciences, Dimers (Chemical physics), medicine.disease, Molecular biology, Isogenic human disease models, Probe Hybridization, respiratory tract diseases, HEK293 Cells, 030104 developmental biology, Chemical Properties, Specimen Preparation and Treatment, Focal Adhesion Protein-Tyrosine Kinases, Mutation, Enzymology, lcsh:Q, Protein Multimerization, Proto-Oncogene Proteins c-akt, Cytogenetic Techniques