Modeling specific action potentials in the human atria based on a minimal single-cell model
| العنوان: | Modeling specific action potentials in the human atria based on a minimal single-cell model |
|---|---|
| المؤلفون: | Philipp Maass, Yvonne Richter, Pedro G. Lind |
| المصدر: | PLoS ONE, Vol 13, Iss 1, p e0190448 (2018) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, RNA viruses, Physiology, Action Potentials, lcsh:Medicine, Plant Science, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Biochemistry, Polynomials, Nonlinear programming, 0302 clinical medicine, Atrial Fibrillation, Medicine and Health Sciences, lcsh:Science, Mathematics, Multidisciplinary, Pharmaceutics, Models, Cardiovascular, Electrophysiology, Tobacco Mosaic Virus, Chemistry, Amplitude, Tobamoviruses, Medical Microbiology, Viral Pathogens, Viruses, Physical Sciences, Pathogens, Biological system, Arrhythmia, Research Article, Chemical Elements, Scale (ratio), Plant Pathogens, Cardiology, Neurophysiology, Bioenergetics, Membrane Potential, Microbiology, Plant Viral Pathogens, Minimal model, 03 medical and health sciences, Drug Therapy, Ionic Current, Effective method, Humans, Heart Atria, Microbial Pathogens, Simulation, Cell model, Sodium, lcsh:R, Organisms, Biology and Life Sciences, Plant Pathology, Action (physics), 030104 developmental biology, Algebra, lcsh:Q, Neuroscience |
| الوصف: | We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a6a21300013aed8d1ebc3c9190183Test http://europepmc.org/articles/PMC5779667?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c95a6a21300013aed8d1ebc3c9190183 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|