The Cardioprotective Effect of Vitamin E (Alpha-Tocopherol) Is Strongly Related to Age and Gender in Mice
| العنوان: | The Cardioprotective Effect of Vitamin E (Alpha-Tocopherol) Is Strongly Related to Age and Gender in Mice |
|---|---|
| المؤلفون: | Jingfeng Wang, Yan Li, Yangxin Chen, Jing-Song Ou, Zhi-Jun Ou, Zhi-Ping Wang, Li Fu, Xiang Liu, Ze-Bang Lin, Xiao-Xia Hu, Xi Zhang |
| المصدر: | PLoS ONE, Vol 10, Iss 9, p e0137405 (2015) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Cardiac function curve, Male, medicine.medical_specialty, Cardiotonic Agents, medicine.medical_treatment, lcsh:Medicine, Myocardial Reperfusion Injury, Ventricular Function, Left, Age and gender, chemistry.chemical_compound, Mice, Sex Factors, Internal medicine, medicine, Animals, Vitamin E, Myocardial infarction, lcsh:Science, Multidisciplinary, business.industry, lcsh:R, Age Factors, medicine.disease, Cardiovascular physiology, Mice, Inbred C57BL, Endocrinology, chemistry, Apoptosis, Female, lcsh:Q, business, alpha-Tocopherol, Research Article |
| الوصف: | Vitamin E (VitE) only prevented cardiovascular diseases in some patients and the mechanisms remain unknown. VitE levels can be affected by aging and gender. We hypothesize that age and gender can influence VitE’s cardioprotective effect. Mice were divided into 4 groups according to age and gender, and each group of mice were divided into a control group and a VitE group. The mice were administered water or VitE for 21 days; Afterward, the cardiac function and myocardial infarct size and cardiomyocyte apoptosis were measured after myocardial ischemia reperfusion(MI/R). VitE may significantly improved cardiac function in young male mice and aged female mice by enhancing ERK1/2 activity and reducing JNK activity. Enhanced expression of HSP90 and Bcl-2 were also seen in young male mice. No changes in cardiac function and cardiac proteins were detected in aged male mice and VitE was even liked to exert a reverse effect in cardiac function in young mice by enhancing JNK activity and reducing Bcl-2 expression. Those effects were in accordance with the changes of myocardial infarction size and cardiomyocyte apoptosis in each group of mice. VitE may reduce MI/R injury by inhibiting cardiomyocyte apoptosis in young male mice and aged female mice but not in aged male mice. VitE was possibly harmful for young female mice, shown as increased cardiomyocyte apoptosis after MI/R. Thus, we speculated that the efficacy of VitE in cardiac protection was associated with age and gender. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf703c6322d394eb1ce9739eb2a2ccdTest http://europepmc.org/articles/PMC4557942?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....abf703c6322d394eb1ce9739eb2a2ccd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|