Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse
| العنوان: | Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse |
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| المؤلفون: | Elena Vecile, Benjamin W. Van Tassell, Fadi N Salloum, Aldo Dobrina, Ignacio M. Seropian, Stefano Toldo, Antonio Abbate, Eleonora Mezzaroma |
| المساهمون: | Abbate, A., Salloum, F. N., Van Tassell, B. W., Vecile, E., Toldo, S., Seropian, I., Mezzaroma, E., Dobrina, Aldo |
| المصدر: | PLoS ONE, Vol 6, Iss 11, p e27923 (2011) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Anatomy and Physiology, Myocardial Infarction, lcsh:Medicine, 030204 cardiovascular system & hematology, Cardiovascular, Mice, 0302 clinical medicine, Immune Physiology, cytokine, Myocytes, Cardiac, Myocardial infarction, lcsh:Science, remodeling, 0303 health sciences, Multidisciplinary, Ejection fraction, TUNEL assay, Ventricular Remodeling, apoptosis, Interleukin, Receptor antagonist, Cardiology, Cytokines, Medicine, Research Article, medicine.medical_specialty, Systole, medicine.drug_class, Heart Ventricles, Immunology, ischemia, Microbiology, 03 medical and health sciences, Internal medicine, medicine, Animals, cardiovascular diseases, Ventricular remodeling, Biology, pharmacology, 030304 developmental biology, Inflammation, Heart Failure, business.industry, Myocardium, lcsh:R, Immunity, Molecular Development, medicine.disease, apoptosi, Survival Analysis, Mice, Inbred C57BL, Interleukin 1 Receptor Antagonist Protein, Endocrinology, Interleukin 1 receptor antagonist, Immune System, Clinical Immunology, lcsh:Q, business, Interleukin-1, Developmental Biology |
| الوصف: | BACKGROUND: Healing after acute myocardial infarction (AMI) is characterized by an intense inflammatory response and increased Interleukin-1 (IL-1) tissue activity. Genetically engineered mice lacking the IL-1 receptor (IL-1R1-/-, not responsive to IL-1) or the IL-1 receptor antagonist (IL-1Ra, enhanced response to IL-1) have an altered IL-1/IL-1Ra balance that we hypothesize modulates infarct healing and cardiac remodeling after AMI. METHODS: IL-1R1-/- and IL-1Ra-/- male mice and their correspondent wild-types (WT) were subjected to permanent coronary artery ligation or sham surgery. Infarct size (trichrome scar size), apoptotic cell death (TUNEL) and left ventricular (LV) dimensions and function (echocardiography) were measured prior to and 7 days after surgery. RESULTS: When compared with the corresponding WT, IL-1R1-/- mice had significantly smaller infarcts (-25%), less cardiomyocyte apoptosis (-50%), and reduced LV enlargement (LV end-diastolic diameter increase [LVEDD], -20%) and dysfunction (LV ejection fraction [LVEF] decrease, -50%), whereas IL-1Ra-/- mice had significantly larger infarcts (+75%), more apoptosis (5-fold increase), and more severe LV enlargement (LVEDD increase,+30%) and dysfunction (LVEF decrease, +70%)(all P values |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec8898cd65b653ac9dabea11828005fTest http://europepmc.org/articles/PMC3225370?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ec8898cd65b653ac9dabea11828005f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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