Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products
| العنوان: | Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products |
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| المؤلفون: | N.S. Mason, Judson M. Englert, Pavle S. Milutinovic, Tim D. Oury, Louis J. Sparvero, Lauren T. Crum, Lasse Ramsgaard, Jan J. Enghild, Michael T. Lotze |
| المصدر: | PLoS ONE, Vol 9, Iss 3, p e88259 (2014) PLoS ONE Milutinovic, P S, Englert, J M, Crum, L T, Mason, N S, Ramsgaard, L, Enghild, J J, Sparvero, L J, Lotze, M T & Oury, T D 2014, ' Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products ', PLOS ONE, vol. 9, no. 3, pp. e88259 . https://doi.org/10.1371/journal.pone.0088259Test |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Proteomics, Male, Receptor for Advanced Glycation End Products, lcsh:Medicine, Plasma protein binding, Pharmacology, Biochemistry, RAGE (receptor), Extracellular matrix, Mice, 0302 clinical medicine, Laminin, Glycation, Molecular Cell Biology, Tissue Distribution, Biomacromolecule-Ligand Interactions, Receptors, Immunologic, Receptor, lcsh:Science, Lung, 0303 health sciences, Extracellular Matrix Proteins, Multidisciplinary, biology, Chemistry, 3. Good health, Extracellular Matrix, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Injections, Intravenous, Cytochemistry, Cellular Structures and Organelles, Injections, Intraperitoneal, Research Article, Protein Binding, Collagen Type IV, Serum albumin, Biological Availability, Collagen Type I, 03 medical and health sciences, Administration, Inhalation, medicine, Animals, Humans, Protein Interactions, 030304 developmental biology, Basement membrane, lcsh:R, Biology and Life Sciences, Proteins, Biological Transport, Cell Biology, Fibronectins, Mice, Inbred C57BL, Kinetics, Metabolism, Solubility, Immunology, biology.protein, lcsh:Q |
| الوصف: | Elucidating the sites and mechanisms of sRAGE action in the healthy state is vital to better understand the biological importance of the receptor for advanced glycation end products (RAGE). Previous studies in animal models of disease have demonstrated that exogenous sRAGE has an anti-inflammatory effect, which has been reasoned to arise from sequestration of pro-inflammatory ligands away from membrane-bound RAGE isoforms. We show here that sRAGE exhibits in vitro binding with high affinity and reversibly to extracellular matrix components collagen I, collagen IV, and laminin. Soluble RAGE administered intratracheally, intravenously, or intraperitoneally, does not distribute in a specific fashion to any healthy mouse tissue, suggesting against the existence of accessible sRAGE sinks and receptors in the healthy mouse. Intratracheal administration is the only effective means of delivering exogenous sRAGE to the lung, the organ in which RAGE is most highly expressed; clearance of sRAGE from lung does not differ appreciably from that of albumin. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9397f4f1078ac9f09f3aa01753d1f1eTest http://europepmc.org/articles/PMC3958346?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a9397f4f1078ac9f09f3aa01753d1f1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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