Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling
| العنوان: | Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling |
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| المؤلفون: | Hyung-Seok Kim, Myung Ho Jeong, Ming Quan Lin, Li Jin, Yuhee Ryu, Zhe Hao Piao, Hae Jin Kee, Sin Young Choi, Jung Ha Kim, Gwi Ran Kim |
| المصدر: | PLOS ONE(11): 11 PLoS ONE PLoS ONE, Vol 11, Iss 11, p e0167340 (2016) |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cell signaling, Protein Expression, lcsh:Medicine, Signal transduction, Kidney, urologic and male genital diseases, p38 Mitogen-Activated Protein Kinases, Biochemistry, Vascular Medicine, Mice, chemistry.chemical_compound, 0302 clinical medicine, Ischemia, Fibrosis, Stilbenes, Medicine and Health Sciences, lcsh:Science, Piceatannol, Extracellular Matrix Proteins, Histone deacetylase 5, Multidisciplinary, Signaling cascades, Animal Models, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Anatomy, Renal Ischemia, Ureteral Obstruction, Research Article, Cell biology, medicine.medical_specialty, Epithelial-Mesenchymal Transition, MAPK signaling cascades, MAP Kinase Signaling System, SMAD signaling, Down-Regulation, Mouse Models, Biology, Research and Analysis Methods, Gene Expression Regulation, Enzymologic, Histone Deacetylases, 03 medical and health sciences, Model Organisms, Internal medicine, Gene Expression and Vector Techniques, medicine, Renal fibrosis, Animals, Molecular Biology Techniques, Molecular Biology, Molecular Biology Assays and Analysis Techniques, Renal ischemia, urogenital system, lcsh:R, Biology and Life Sciences, Proteins, Kidneys, Renal System, medicine.disease, HDAC4, Mice, Inbred C57BL, CTGF, 030104 developmental biology, Endocrinology, chemistry, Cancer research, lcsh:Q, Collagens, Biomarkers, Developmental Biology |
| الوصف: | Piceatannol, a resveratrol metabolite, is a phenolic compound found in red wine and grapes. We investigated the effect of piceatannol on renal fibrosis and histone deacetylase (HDAC) expression in a mouse model of unilateral ureteral obstruction (UUO). Fibrosis was established by UUO and piceatannol was intraperitoneally injected for 2 weeks. Piceatannol suppressed extracellular matrix (ECM) protein deposition including collagen type I and fibronectin as well as connective tissue growth factor (CTGF) and α-smooth muscle actin (α-SMA) in UUO kidneys. However, the expressions of epithelial-mesenchymal transition (EMT) marker genes, such as N-cadherin and E-cadherin, were not changed in the kidneys after UUO. Masson's trichrome staining and fluorescence immunostaining showed that piceatannol administration attenuated collagen deposition in UUO kidneys. HDAC1, HDAC4, HDAC5, HDAC6, and HDAC10 protein expression was upregulated in UUO kidneys, whereas that of HDAC8 was downregulated. Piceatannol treatment significantly reduced HDAC4 and HDAC5 protein expression. Further, piceatannol attenuated phosphorylation of p38 mitogen-activated protein kinase (p38-MAPK) in UUO kidneys, but not that of transforming growth factor beta1-Smad2/3. These results suggest that class I HDACs and class IIa/b HDACs are involved in renal fibrosis development. Piceatannol may be a beneficial therapeutic agent for treating renal fibrosis via reduction of HDAC4 and HDAC5 protein expression or suppression of the p38-MAPK signaling pathway. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a3c1148bf9b290ab242039a229d5c7Test https://doi.org/10.1371/journal.pone.0167340Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....65a3c1148bf9b290ab242039a229d5c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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