Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure: impact of an oral glucose load
| العنوان: | Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure: impact of an oral glucose load |
|---|---|
| المؤلفون: | Michael Madsen, Jens Otto Lunde Jørgensen, Niels Møller, Thomas Krusenstjerna-Hafstrøm, Jens Sandahl Christiansen, Steen B. Pedersen, Niels Jessen, Mikkel H. Vendelbo |
| المصدر: | PLoS ONE, Vol 6, Iss 5, p e19392 (2011) Hafstrøm, T K, Madsen, M, Vendelbo, M H, Pedersen, S B, Christiansen, J S, Møller, N, Jessen, N & Jørgensen, J O L 2011, ' Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure : impact of an oral glucose load ', P L o S One, vol. 6, no. 5, pp. e19392 . https://doi.org/10.1371/journal.pone.0019392Test PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Biopsy, Administration, Oral, lcsh:Medicine, Fatty Acids, Nonesterified, Insulin resistance, Bolus (medicine), Endocrinology, Internal medicine, Growth Factors, medicine, Humans, Insulin, Single-Blind Method, Muscle, Skeletal, lcsh:Science, Protein kinase B, Diabetic Endocrinology, Glucose tolerance test, Multidisciplinary, Cross-Over Studies, biology, medicine.diagnostic_test, Endocrine Physiology, Human Growth Hormone, lcsh:R, Skeletal muscle, Diabetes Mellitus Type 2, Glucose Tolerance Test, medicine.disease, Insulin receptor, medicine.anatomical_structure, Glucose, Pituitary, Gene Expression Regulation, Area Under Curve, biology.protein, Medicine, lcsh:Q, Signal transduction, Research Article, Signal Transduction |
| الوصف: | Introduction GH induces acute insulin resistance in skeletal muscle in vivo, which in rodent models has been attributed to crosstalk between GH and insulin signaling pathways. Our objective was to characterize time course changes in signaling pathways for GH and insulin in human skeletal muscle in vivo following GH exposure in the presence and absence of an oral glucose load. Methods Eight young men were studied in a single-blinded randomized crossover design on 3 occasions: 1) after an intravenous GH bolus 2) after an intravenous GH bolus plus an oral glucose load (OGTT), and 3) after intravenous saline plus OGTT. Muscle biopsies were taken at t = 0, 30, 60, and 120. Blood was sampled at frequent intervals for assessment of GH, insulin, glucose, and free fatty acids (FFA). Results GH increased AUCglucose after an OGTT (p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b062a6e6ce06d1d195bd9093011b7311Test http://europepmc.org/articles/PMC3086909?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b062a6e6ce06d1d195bd9093011b7311 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|