Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity
| العنوان: | Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity |
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| المؤلفون: | Susanna B. Park, Arun V. Krishnan, Michael Friedlander, Cindy S.-Y. Lin, Matthew C. Kiernan, David Goldstein |
| المصدر: | PLoS ONE, Vol 6, Iss 4, p e18469 (2011) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Organoplatinum Compounds, Colorectal cancer, medicine.medical_treatment, Cancer Treatment, lcsh:Medicine, Pharmacology, Toxicology, Sodium Channels, Ion Channels, 0302 clinical medicine, Dose effect, Clinical Trials (Cancer Treatment), Infusions, Intravenous, lcsh:Science, Aged, 80 and over, Clinical Neurophysiology, Multidisciplinary, Movement Disorders, Clinical Pharmacology, Middle Aged, 3. Good health, Cancer treatment, Oxaliplatin, Neurology, Oncology, 030220 oncology & carcinogenesis, Anesthesia, Medicine, Female, Oncology Agents, Ion Channel Gating, medicine.drug, Research Article, Adult, Neurotoxicology, Drugs and Devices, Drug Research and Development, Neurotoxins, 03 medical and health sciences, Neuropharmacology, Channelopathy, Diagnostic Medicine, medicine, Humans, Biology, Demography, Chemotherapy, Dose-Response Relationship, Drug, business.industry, lcsh:R, Neurotoxicity, Chemotherapy and Drug Treatment, medicine.disease, Axons, Cellular Neuroscience, Sensory neuropathy, lcsh:Q, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | BACKGROUND: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces two forms of neurotoxicity--acute sensorimotor neuropathic symptoms and a dose-limiting chronic sensory neuropathy. Given that a Na(+) channelopathy has been proposed as the mechanism underlying acute oxaliplatin-induced neuropathy, the present study aimed to determine specific mechanisms of Na(+) channel dysfunction. METHODOLOGY/PRINCIPAL FINDINGS: Specifically the function of transient and persistent Na(+) currents were followed during treatment and were investigated in relation to oxaliplatin dose level. Eighteen patients were assessed before and after a single oxaliplatin infusion with motor and sensory axonal excitability studies performed on the median nerve at the wrist. While refractoriness (associated with Na(+) channel inactivation) was significantly altered post-oxaliplatin infusion in both motor (Pre: 31.7±6.4%; Post: 68.8±14.5%; P≤.001) and sensory axons (Pre: 31.4±5.4%; Post: 21.4±5.5%; P |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ae62bc542dd262d490438cc85b6a90Test http://europepmc.org/articles/PMC3072981?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0ae62bc542dd262d490438cc85b6a90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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