CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease
| العنوان: | CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease |
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| المؤلفون: | Tracey K. Murray, Michael J. O'Neill, Seth Love, Nina Balthasar, Heather J. Weir, Jon D. Lane, Eric Verdin, Patrick G. Kehoe |
| المصدر: | PLoS ONE, Vol 7, Iss 11, p e48225 (2012) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Mitochondrial ROS, Central Nervous System, Mouse, Gene Expression, lcsh:Medicine, Mitochondrion, medicine.disease_cause, Mice, Oxidative Damage, Sirtuin 3, Molecular Cell Biology, Neurobiology of Disease and Regeneration, Basic Cancer Research, lcsh:Science, Cellular Stress Responses, chemistry.chemical_classification, Neurons, Multidisciplinary, biology, Cell Death, Animal Models, Cell biology, Mitochondria, Up-Regulation, Oncology, Sirtuin, Medicine, Alzheimer's disease, Neuroglia, Subcellular Fractions, Research Article, SIRT3, Clinical Research Design, Neuroprotection, Electron Transport, Model Organisms, Alzheimer Disease, medicine, Animals, Humans, RNA, Messenger, Animal Models of Disease, Biology, Reactive oxygen species, Amyloid beta-Peptides, Lentivirus, lcsh:R, medicine.disease, Rats, Disease Models, Animal, HEK293 Cells, chemistry, Cellular Neuroscience, Immunology, biology.protein, lcsh:Q, Reactive Oxygen Species, Oxidative stress, HeLa Cells, Neuroscience |
| الوصف: | Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzheimer’s disease (AD)-mediated stress. Pharmacological augmentation of mitochondrial ROS increases Sirt3 expression in primary hippocampal culture with SIRT3 over-expression being neuroprotective. Furthermore, Sirt3 expression mirrors spatiotemporal deposition of β-amyloid in an AD mouse model and is also upregulated in AD patient temporal neocortex. Thus, our data suggest a role for SIRT3 in mechanisms sensing and tackling ROS- and AD-mediated mitochondrial stress. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3278b2c8059a185bf49ccededa068389Test http://europepmc.org/articles/PMC3491018?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3278b2c8059a185bf49ccededa068389 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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