Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer
| العنوان: | Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer |
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| المؤلفون: | Sun-Jun Yin, Can-Hu Zhao, Gonghao He, Zhengping Yu, Jia-Ji Lin, Gui-Li Xu, Wen-Mang Xu, Wen-Ke Cai |
| المصدر: | PLoS ONE, Vol 9, Iss 5, p e97728 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, China, Histamine N-Methyltransferase, Genotype, Gene Identification and Analysis, Gene Expression, lcsh:Medicine, Single-nucleotide polymorphism, Breast Neoplasms, Histidine Decarboxylase, Polymorphism, Single Nucleotide, Metastasis, Histamine receptor, Breast cancer, Breast Tumors, Breast Cancer, medicine, Genetics, Cancer Genetics, Medicine and Health Sciences, Humans, Receptors, Histamine H3, Genetic Predisposition to Disease, lcsh:Science, Alleles, Genetic Association Studies, Multidisciplinary, Histamine N-methyltransferase, business.industry, Haplotype, Carcinoma, Ductal, Breast, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Middle Aged, medicine.disease, Histidine decarboxylase, Oncology, Immunology, Genetics of Disease, Female, Epigenetics, lcsh:Q, business, Research Article |
| الوصف: | We previously found that genetic polymorphisms in gene coding for histamine H4 receptors were related to the risk and malignant degree of breast cancer. The roles of polymorphisms in other histamine-related genes, such as histidine decarboxylase (HDC), histamine N-methyltransferase (HNMT) and histamine H3 receptor (HRH3), remain unexplored. The aim of this study is to analyze the clinical associations of polymorphisms in HDC, HNMT and HRH3 with breast cancer. Two hundred and one unrelated Chinese Han breast cancer patients and 205 ethnicity-matched health controls were recruited for case-control investigation. Genomic DNA from the participants was extracted and 5 single nucleotide polymorphisms (SNPs) in HDC, HNMT and HRH3 were genotyped. We found that polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. However, the T allele of rs7164386 in HDC significantly decreased the risk of breast cancer (adjusted odds ratios [ORs], 0.387; 95% confidence intervals [CIs], 0.208–0.720; P = 0.003). Furthermore, for HDC haplotypes, the CG haplotype of rs7164386-rs7182203 was more frequent among breast cancer patients (adjusted OR, 1.828; 95% CI, 1.218–2.744; P = 0.004) while the TG haplotype was more frequent among health controls (adjusted OR, 0.351; 95% CI, 0.182–0.678; P = 0.002). These findings indicated that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. Further studies with larger participants worldwide are still needed for conclusion validation. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bec5ba343ddba7f5893162d9be07c6Test http://europepmc.org/articles/PMC4023951?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03bec5ba343ddba7f5893162d9be07c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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