Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03
| العنوان: | Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03 |
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| المؤلفون: | Shoji Sugii, Shunsei Hirohata, Aya Kawasaki, Satoshi Ito, Kota Shimada, Ikue Ito, Noriyuki Chiba, Akira Okamoto, Naoyuki Tsuchiya, Kiyoshi Migita, Atsushi Hashimoto, Shigeru Ohno, Hiroshi Furukawa, Hajime Kono, Taichi Hayashi, Hiroshi Hashimoto, Keigo Setoguchi, Takayuki Sumida, Shomi Oka, Hirofumi Amano, Masao Katayama, Isao Matsumoto, Yuya Kondo, Makio Kusaoi, Shouhei Nagaoka, Yoshinari Takasaki, Shigeto Tohma, Tatsuo Nagai, Eiichi Suematsu, Akiko Komiya, Naoshi Fukui, Akiko Suda |
| المصدر: | PLoS ONE, Vol 9, Iss 2, p e87792 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, lcsh:Medicine, Autoimmunity, Polymerase Chain Reaction, Biochemistry, Major Histocompatibility Complex, immune system diseases, Genotype, Odds Ratio, Genetics of the Immune System, Lupus Erythematosus, Systemic, skin and connective tissue diseases, lcsh:Science, Multidisciplinary, Middle Aged, Medicine, Female, Research Article, Adult, Immunology, HLA-DR6 Antigen, Human leukocyte antigen, Biology, Systemic Lupus Erythematosus, Autoimmune Diseases, Asian People, Rheumatology, medicine, Genetics, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Alleles, Lupus erythematosus, Lupus Erythematosus, Haplotype, lcsh:R, Autoantibody, Proteins, Odds ratio, DNA, Major Histocompatibility Antigens, medicine.disease, Case-Control Studies, Genetic Polymorphism, Clinical Immunology, lcsh:Q, Population Genetics, HLA-DRB1 Chains |
| الوصف: | Many studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic lupus erythematosus (SLE) have been performed. However, few protective associations with HLA-DRB1 alleles have been reported. Here, we sought protective, as well as predispositional, alleles of HLA-DRB1 in Japanese SLE patients. An association study was conducted for HLA-DRB1 in Japanese SLE patients. Relative predispositional effects were analyzed by sequential elimination of carriers of each allele with the strongest association. We also explored the association of DRB1 alleles with SLE phenotypes including the presence of autoantibody and clinical manifestations. Significantly different carrier frequencies of certain DRB1 alleles were found to be associated with SLE as follows: increased DRB1*15:01 (P = 5.48×10−10, corrected P (Pc) = 1.59×10−8, odds ratio [OR] 2.17, 95% confidence interval [CI] 1.69–2.79), decreased DRB1*13:02 (P = 7.17×10−5, Pc = 0.0020, OR 0.46, 95% CI 0.34–0.63) and decreased DRB1*14:03 (P = 0.0010, Pc = 0.0272, OR 0.34, 95% CI 0.18–0.63). Additionally, the “*15:01/*13:02 or *14:03” genotype tended to be negatively associated with SLE (P = 0.4209, OR 0.66), despite there being significant positive associations with *15:01 when present together with alleles other than *13:02 or *14:03 (P = 1.79×10−11, OR 2.39, 95% CI 1.84–3.10). This protective effect of *13:02 and *14:03 was also confirmed in SLE patients with different clinical phenotypes. To the best of our knowledge, this is the first report of a protective association between the carrier frequencies of HLA-DRB1*13:02 and *14:03 and SLE in the Japanese population. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8930ed88ab62f7602a5871473d62cfTest http://europepmc.org/articles/PMC3912000?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df8930ed88ab62f7602a5871473d62cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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