نتائج البحث - "Sequestosome-1"

1

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

المؤلفون: Donna D. Zhang, Eli Chapman, Pengfei Liu, Matthew Dodson, Deyu Fang

المصدر: PLoS Biology, Vol 18, Iss 2, p e3000620 (2020)
PLoS Biology

مصطلحات موضوعية: 0301 basic medicine, Gene Expression, Biochemistry, environment and public health, Gene Knockout Techniques, Mice, 0302 clinical medicine, Cell Signaling, Sequestosome-1 Protein, Biology (General), Cells, Cultured, Inclusion Bodies, education.field_of_study, General Neuroscience, Cilium, Luciferase Assay, respiratory system, Hedgehog signaling pathway, 3. Good health, Cell biology, Enzymes, Patched-1 Receptor, Immunoblot Analysis, Bioassays and Physiological Analysis, Signal transduction, Cellular Structures and Organelles, General Agricultural and Biological Sciences, Oxidoreductases, Microtubule-Associated Proteins, Luciferase, Signal Transduction, Research Article, Patched, NF-E2-Related Factor 2, QH301-705.5, Immunoblotting, Molecular Probe Techniques, Biology, Research and Analysis Methods, digestive system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Sequestosome 1, Tubulins, Ciliogenesis, DNA-binding proteins, Genetics, Animals, Humans, Hedgehog Proteins, Gene Regulation, Cilia, education, Molecular Biology Techniques, Transcription factor, Hedgehog, Molecular Biology, Enzyme Assays, General Immunology and Microbiology, Biology and Life Sciences, Proteins, Cell Biology, Antioxidant Response Elements, Regulatory Proteins, Cytoskeletal Proteins, 030104 developmental biology, Hedgehog Signaling, Enzymology, Biochemical Analysis, 030217 neurology & neurosurgery, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0255ee871931083b44e5100ea75c5071Test
https://doaj.org/article/85870749871a48f897298f43e7e78f1eTest

2

The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice

المؤلفون: Sei-Gyung K. Sze, Catherine Lavau, Sarah A. Port, Ralph H. Kehlenbach, Waitman K. Aumann, Veerain Gupta, Daniel S. Wechsler, Katelyn Ripple

المصدر: PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0232036 (2020)

مصطلحات موضوعية: 0301 basic medicine, Oncogene Proteins, Fusion, Amino Acid Motifs, Receptors, Cytoplasmic and Nuclear, medicine.disease_cause, Biochemistry, Hematologic Cancers and Related Disorders, Cell Fusion, Mice, 0302 clinical medicine, Animal Cells, Sequestosome-1 Protein, Medicine and Health Sciences, Blood and Lymphatic System Procedures, Myeloid Ecotropic Viral Integration Site 1 Protein, Bone Marrow Transplantation, Regulation of gene expression, Mutation, Leukemia, Multidisciplinary, Cell fusion, Myeloid leukemia, Hematology, Up-Regulation, Cell biology, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Medicine, Cellular Types, Research Article, Cell Physiology, Science, Bone Marrow Cells, Surgical and Invasive Medical Procedures, Karyopherins, Biology, DNA-binding protein, Cell Line, Digestive System Procedures, 03 medical and health sciences, Protein Domains, Leukemias, DNA-binding proteins, medicine, Animals, Point Mutation, Homeobox, Protein Interactions, Nuclear export signal, Homeodomain Proteins, Transplantation, Cancers and Neoplasms, Biology and Life Sciences, Proteins, Cell Biology, Organ Transplantation, Fusion protein, Liver Transplantation, Nuclear Pore Complex Proteins, 030104 developmental biology, Mutagenesis, Site-Directed, Chromatin immunoprecipitation, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8aa6b22865b99e13ad03bd5d63c6c8Test
https://doi.org/10.1371/journal.pone.0232036Test

3

Molecular effect of an OPTN common variant associated to Paget's disease of bone

المؤلفون: Iris A.L. Silva, M. Leonor Cancela, Edith Gagnon, Laëtitia Michou, Natércia Conceição, Jacques P. Brown

المصدر: PLoS ONE, Vol 13, Iss 5, p e0197543 (2018)
PLoS ONE
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Identification, Candidate gene, Heredity, Transcription Factor, Physiology, Protein Data Bank (RCSB PDB), Osteoclasts, lcsh:Medicine, Cell Cycle Proteins, Biochemistry, Animal Cells, Transcription Factor TFIIIA, Sequestosome-1 Protein, Medicine and Health Sciences, lcsh:Science, Connective Tissue Cells, Optineurin, Genetics, education.field_of_study, DNA methylation, Multidisciplinary, Genetic-Heterogeneity, Chromosome 18Q, Cell Death, Linkage, NF-kappa B, Cell Differentiation, Chromatin, Up-Regulation, Nucleic acids, Genetic Mapping, Connective Tissue, Cell Processes, Epigenetics, Bone Remodeling, Anatomy, Cellular Types, DNA modification, Autophagy Receptor, Chromatin modification, Research Article, Chromosome biology, Locus, Autophagic Cell Death, Active Transport, Cell Nucleus, information science, Variant Genotypes, Locus (genetics), macromolecular substances, Biology, Polymorphism, Single Nucleotide, Cell Line, 03 medical and health sciences, Sequestosome 1, Autophagy, medicine, Humans, Genetic Predisposition to Disease, natural sciences, Bone Resorption, Allele, Bone, education, Gene, Alleles, Genetic Association Studies, lcsh:R, Biology and Life Sciences, Genetic Variation, Membrane Transport Proteins, Kappa-B Activation, Cell Biology, DNA, Binding, Osteitis Deformans, medicine.disease, Introns, Biological Tissue, 030104 developmental biology, Paget's disease of bone, Haplotypes, Genetic Loci, Mutation, health occupations, lcsh:Q, Gene expression, Physiological Processes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75fb885e1d6ff5178081d79944f80abTest
http://europepmc.org/articles/PMC5962077?pdf=renderTest

4

Lysosomal adaptation: How cells respond to lysosomotropic compounds

المؤلفون: Bart Jessen, Robert T. Abraham, Tae Sung, Nianwei Lin, Shuyan Lu

المصدر: PLoS ONE, Vol 12, Iss 3, p e0173771 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Gene Expression, lcsh:Medicine, mTORC1, Retinal Pigment Epithelium, Biochemistry, Sequestosome-1 Protein, Medicine and Health Sciences, Small interfering RNAs, lcsh:Science, Glyceraldehyde 3-phosphate dehydrogenase, Cellular Stress Responses, Multidisciplinary, LAMP2, biology, Cell Death, Chemistry, Pharmaceutics, Glyceraldehyde-3-Phosphate Dehydrogenases, Drugs, Chloroquine, Hydrogen-Ion Concentration, Adaptation, Physiological, Cell biology, Nucleic acids, Cell Processes, Signal transduction, Cellular Structures and Organelles, Intracellular, Research Article, Autophagic Cell Death, Biosynthesis, Cell Line, 03 medical and health sciences, Antimalarials, Drug Therapy, DNA-binding proteins, Extracellular, Genetics, Humans, Gene Regulation, Non-coding RNA, Cathepsin, Pharmacology, Opsins, lcsh:R, Biology and Life Sciences, Proteins, Cell Biology, Regulatory Proteins, 030104 developmental biology, biology.protein, TFEB, RNA, lcsh:Q, Lysosomes, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb50b1d4090b92a59c2ffda774a799aeTest
http://europepmc.org/articles/PMC5354416?pdf=renderTest

5

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis

المؤلفون: Solenn M. Guilbert, Josée N. Lavoie, Herman Lambert, Jacques Landry, Alice-Anaïs Varlet, Alexandra Jetté, Sabine Elowe, Carole Luthold, Margit Fuchs

المصدر: PLoS Genetics, Vol 11, Iss 10, p e1005582 (2015)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, Mitosis, Spindle Apparatus, Polo-like kinase, Protein Serine-Threonine Kinases, Biology, QH426-470, Spindle pole body, 03 medical and health sciences, 0302 clinical medicine, Chromosome Segregation, Sequestosome-1 Protein, Autophagy, Concanavalin A, Genetics, Humans, RNA, Small Interfering, Molecular Biology, Heat-Shock Proteins, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Adaptor Proteins, Signal Transducing, 030304 developmental biology, 0303 health sciences, Kinetochore, Cell biology, Spindle apparatus, Actin Cytoskeleton, Spindle checkpoint, Proteolysis, MCF-7 Cells, Chaperone complex, Apoptosis Regulatory Proteins, Multipolar spindles, Heat-Shock Response, 030217 neurology & neurosurgery, HeLa Cells, Molecular Chaperones, Protein Binding, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d9853b0e8dcb8dc3cc8013fbc8ff2aTest
https://doaj.org/article/523288e564ad48df9ff97d2de4d343aaTest

6

HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation

المؤلفون: Jian Xuan Zou, Frank K. Braun, Jinle Tang, Lin Yang, Chao Wu, Fei Xu, Xingding Zhang, Xue Sun, Gang Li An, Ji Gang Zhang, Lin Qi, Zhiqiang Liu, Hui Han Wang, Fenge Li, Hui Min Meng, Kui Zhao, Feng Rui Lei, Bao‑Song Zhu, Luis A. Velasquez, Yun Tian Shen

المصدر: PLoS ONE, Vol 10, Iss 11, p e0142901 (2015)
PLoS ONE

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710f4ccd4626752dcd25381e943aef55Test
http://europepmc.org/articles/PMC4643922?pdf=renderTest

7

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

المؤلفون: Chengjun Hu, Changhua Wang, Jinbao Liu, Yihao Tian, Zongwen Tian, Xuejun Wang

المصدر: PLoS ONE, Vol 9, Iss 6, p e100715 (2014)
PLoS ONE

مصطلحات موضوعية: Sequestosome-1 Protein, Genetically modified mouse, Proteasome Endopeptidase Complex, Ubiquitin-Proteasome System, Cardiology, lcsh:Medicine, Antineoplastic Agents, Mice, Transgenic, 030204 cardiovascular system & hematology, Biochemistry, Bortezomib, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, In vivo, Heat shock protein, Medicine and Health Sciences, Autophagy, Myocyte, Animals, Myocytes, Cardiac, lcsh:Science, Heat-Shock Proteins, 030304 developmental biology, 0303 health sciences, Gene knockdown, Multidisciplinary, biology, Adenine, lcsh:R, Biology and Life Sciences, Proteins, Cell Biology, Molecular biology, Boronic Acids, Cell biology, Rats, Proteasome, Pyrazines, Proteolysis, biology.protein, lcsh:Q, Cellular Structures and Organelles, Lysosomes, Proteasome Inhibitors, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8081ef1fe0ac1adfad8461216bffcee1Test
http://europepmc.org/articles/PMC4069113?pdf=renderTest

8

SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity

المؤلفون: Luis Calderilla-Barbosa, Michael L. Seibenhener, Jin Yan, Marie W. Wooten, Jorge Moscat, Jianxiong Jiang, Michael C. Wooten, Maria-Theresa Diaz-Meco

المصدر: PLoS ONE, Vol 8, Iss 9, p e76016 (2013)
PLoS ONE

مصطلحات موضوعية: Sequestosome-1 Protein, Blotting, Western, lcsh:Medicine, Protein aggregation, Protein degradation, Histone Deacetylase 6, Histone Deacetylases, 03 medical and health sciences, 0302 clinical medicine, Sequestosome 1, Protein Interaction Mapping, Autophagy, Humans, Immunoprecipitation, education, lcsh:Science, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Glutathione Transferase, 0303 health sciences, education.field_of_study, Multidisciplinary, biology, lcsh:R, HDAC6, Actins, Ubiquitin ligase, Cell biology, Aggresome, HEK293 Cells, Microscopy, Fluorescence, 030220 oncology & carcinogenesis, Proteolysis, biology.protein, lcsh:Q, Microtubule-Organizing Center, Deacetylase activity, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf33234596983d8a1586d226d0c41c8Test
http://europepmc.org/articles/PMC3785417?pdf=renderTest

9

Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1

المؤلفون: Aniket Nikam, Kurt Zatloukal, Jay V. Patankar, Elisabeth Schöck, Carolin Lackner, Peter M. Abuja, Dagmar Kratky

المصدر: PLoS ONE, Vol 8, Iss 6, p e66094 (2013)
PLoS ONE

مصطلحات موضوعية: Male, Protein Folding, Anatomy and Physiology, Time Factors, Mouse, Alcoholic Liver Disease, Pyridines, Gene Expression, lcsh:Medicine, Nonalcoholic Steatohepatitis, Mitochondrion, Mallory Bodies, medicine.disease_cause, Biochemistry, Mice, 0302 clinical medicine, Adenosine Triphosphate, Molecular Cell Biology, Sequestosome-1 Protein, lcsh:Science, Energy-Producing Organelles, Heat-Shock Proteins, Cellular Stress Responses, 0303 health sciences, Multidisciplinary, biology, Liver Diseases, Fatty liver, Animal Models, Oxygen Metabolism, 3. Good health, Mitochondria, Liver, 030220 oncology & carcinogenesis, Chemical and Drug Induced Liver Injury, Chronic, Enzyme Induction, Toxicity, Acute Disease, Medicine, Keratins, Chemical and Drug Induced Liver Injury, Research Article, medicine.medical_specialty, Intermediate filament cytoskeleton, Oxidative phosphorylation, Gastroenterology and Hepatology, Bioenergetics, 03 medical and health sciences, Model Organisms, Internal medicine, medicine, Animals, Enzyme inducer, Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Body Weight, lcsh:R, medicine.disease, Heme oxygenase, Oxidative Stress, Endocrinology, Metabolism, Immunology, biology.protein, Hepatocytes, lcsh:Q, Physiological Processes, Energy Metabolism, Oxidative stress, Heme Oxygenase-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b73b9ec417ec6dda33d4d561a18004eTest
http://europepmc.org/articles/PMC3675145?pdf=renderTest

10

Regulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2

المؤلفون: Yuxue Xu, Zuguo Liu, Lingxiang Zhu, Aditya Manoharan, Yin Chen, Erika C. Barret

المصدر: PLoS ONE, Vol 8, Iss 4, p e55695 (2013)
PLoS ONE

مصطلحات موضوعية: Autophagosome, Pulmonology, lcsh:Medicine, Biochemistry, environment and public health, 0302 clinical medicine, Molecular cell biology, RNA interference, Phagosomes, Sequestosome-1 Protein, Protein Isoforms, lcsh:Science, 2. Zero hunger, Regulation of gene expression, 0303 health sciences, Gene knockdown, Multidisciplinary, Kelch-Like ECH-Associated Protein 1, Cell Death, TOR Serine-Threonine Kinases, Smoking, Intracellular Signaling Peptides and Proteins, Aging and Immunity, respiratory system, Innate Immunity, Cell biology, Nucleic acids, 030220 oncology & carcinogenesis, Medicine, Signal transduction, Cellular Types, Microtubule-Associated Proteins, Research Article, Signal Transduction, Programmed cell death, NF-E2-Related Factor 2, Bronchi, Biology, Complex Mixtures, Environmental and Occupational Lung Diseases, digestive system, Cell Line, 03 medical and health sciences, Defense Proteins, Tobacco, Autophagy, Humans, PI3K/AKT/mTOR pathway, 030304 developmental biology, Adaptor Proteins, Signal Transducing, lcsh:R, Immunity, Proteins, Epithelial Cells, KEAP1, Gene Expression Regulation, RNA, Clinical Immunology, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6eae6c65db7a162c8e96a5a3ad46b63Test
http://europepmc.org/articles/PMC3621864?pdf=renderTest

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