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1

A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor

المؤلفون: Christopher D. Smith, Michael N. Weedon, Alistair Jones, Jessica Tyrrell, Jonathan P Evans, Harry D Green, Robin N Beaumont, Timothy M. Frayling, Andrew R. Wood

المصدر: PLoS Genetics, Vol 17, Iss 6 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 6, p e1009577 (2021)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epidemiology, Single Nucleotide Polymorphisms, Genome-wide association study, Type 2 diabetes, Disease, 030204 cardiovascular system & hematology, QH426-470, Bioinformatics, 0302 clinical medicine, Endocrinology, Medical Conditions, Mathematical and Statistical Techniques, Risk Factors, Medicine and Health Sciences, Musculoskeletal System, Genetics (clinical), Statistics, Frozen shoulder, Genomics, Metaanalysis, Middle Aged, Type 2 Diabetes, Dupuytren Contracture, Physical Sciences, Anatomy, Research Article, Adult, Endocrine Disorders, Single-nucleotide polymorphism, Biology, Research and Analysis Methods, Diabetes Complications, 03 medical and health sciences, Bursitis, Mendelian randomization, medicine, Diabetes Mellitus, Genome-Wide Association Studies, Genetics, Humans, Risk factor, Statistical Methods, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Type 1 diabetes, Biology and Life Sciences, Computational Biology, Human Genetics, Mendelian Randomization Analysis, medicine.disease, Genome Analysis, United Kingdom, 030104 developmental biology, Shoulders, Genetic Loci, Metabolic Disorders, Medical Risk Factors, Mathematics, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef9e2d5ec2622b6c9babc123b7fdbfeTest
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191964/?tool=EBITest

2

Utilizing digital pathology to quantify stromal caveolin-1 expression in malignant and benign ovarian tumors: Associations with clinicopathological parameters and clinical outcomes

المؤلفون: Anthony M. Magliocco, Robert M. Wenham, Susan M McCarthy, Sachin M. Apte, Jennifer B. Permuth, Dung-Tsa Chen, Ardeshir Hakam, Johnathan M. Lancaster, Douglas C. Marchion, Daryoush Saeed-Vafa, Alexis S. Lopez, Brett M. Reid

المصدر: PLoS ONE, Vol 16, Iss 11, p e0256615 (2021)
PLoS ONE

مصطلحات موضوعية: endocrine system diseases, Caveolin 1, Cancer Treatment, Epithelium, Metastasis, Breast Tumors, Medicine and Health Sciences, Aged, 80 and over, Ovarian Neoplasms, Multidisciplinary, medicine.diagnostic_test, Prostate Cancer, Prostate Diseases, Obstetrics and Gynecology, Middle Aged, Immunohistochemistry, Ovarian Cancer, Gene Expression Regulation, Neoplastic, Survival Rate, Serous fluid, medicine.anatomical_structure, Oncology, cardiovascular system, Biomarker (medicine), Medicine, Female, Anatomy, Research Article, Adult, Stromal cell, Urology, Science, Down-Regulation, Immunofluorescence, Malignant Tumors, Stroma, Breast Cancer, medicine, Biomarkers, Tumor, Humans, Aged, Neoplasm Staging, business.industry, Ovary, Gynecologic Cancers, Cancers and Neoplasms, Biology and Life Sciences, medicine.disease, Cystadenocarcinoma, Serous, Genitourinary Tract Tumors, Biological Tissue, Tissue Array Analysis, Cancer research, Women's Health, Stromal Cells, business, Gynecological Tumors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccab72a6d0b4a13c7fdbbfce8e00d8eTest
https://doaj.org/article/5ca8a7d61e0f4af186e6fa6b2b9a9a6fTest

3

Genotype-phenotype correlation in neurofibromatosis type-1: NF1 whole gene deletions lead to high tumor-burden and increased tumor-growth

المؤلفون: Peter Bannas, Johannes Salamon, Lan Kluwe, Lennart Well, Gerhard Adam, Victor-Felix Mautner, Kimberly Döbel, Said Farschtschi

المصدر: PLoS Genetics
PLoS Genetics, Vol 17, Iss 5, p e1009517 (2021)

مصطلحات موضوعية: Male, Cancer Research, Epidemiology, Tumor burden, QH426-470, Adolescents, Gene Deletions, Gastroenterology, Diagnostic Radiology, Correlation, Families, Medical Conditions, 0302 clinical medicine, Medicine and Health Sciences, Prevalence, Child, Lead (electronics), Children, Neurological Tumors, Genetics (clinical), Sequence Deletion, 0303 health sciences, Radiology and Imaging, Cancer Risk Factors, Middle Aged, Magnetic Resonance Imaging, Tumor Burden, Deletion Mutation, Cell Transformation, Neoplastic, Oncology, Neurology, Genetic Diseases, Child, Preschool, 030220 oncology & carcinogenesis, Disease Progression, Female, Research Article, Adult, medicine.medical_specialty, Neurofibromatosis 1, Adolescent, Imaging Techniques, Biology, Research and Analysis Methods, Genotype phenotype, Young Adult, 03 medical and health sciences, Malignant Tumors, Diagnostic Medicine, Internal medicine, Genes, Neurofibromatosis 1, Genetics, medicine, Humans, Tumor growth, Neurofibromatosis, Molecular Biology, Gene, Genetic Association Studies, Ecology, Evolution, Behavior and Systematics, Cell Proliferation, 030304 developmental biology, Clinical Genetics, Neurofibroma, Plexiform, Autosomal Dominant Diseases, Cancers and Neoplasms, Biology and Life Sciences, medicine.disease, Age Groups, Medical Risk Factors, Case-Control Studies, Mutation, People and Places, Population Groupings, Neurofibromatosis Type 1, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfe1cf88c61992910f2514f55dd6466Test
https://doi.org/10.1371/journal.pgen.1009517Test

4

Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

المؤلفون: Kimiko Izumo, Atae Utsunomiya, Hiroshi Takashima, Toshio Matsuzaki, Ryuji Kubota, Masahisa Horiuchi, Shuji Izumo, Nobuaki Nakano, Mineki Saito, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Masahiro Nagai

المصدر: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008361 (2020)
PLoS Neglected Tropical Diseases

مصطلحات موضوعية: RNA viruses, Male, 0301 basic medicine, Cell Membranes, RC955-962, Gene Expression, Pathology and Laboratory Medicine, Biochemistry, Tyrosine Kinases, White Blood Cells, 0302 clinical medicine, Proviruses, Animal Cells, immune system diseases, hemic and lymphatic diseases, Arctic medicine. Tropical medicine, Tropical spastic paraparesis, Medicine and Health Sciences, Small interfering RNAs, Proto-Oncogene Proteins c-abl, Human T-lymphotropic virus 1, ABL, T Cells, virus diseases, Middle Aged, Viral Load, Paraparesis, Tropical Spastic, Enzymes, Nucleic acids, Dasatinib, Leukemia, Infectious Diseases, Medical Microbiology, Viral Pathogens, Viruses, Female, Cellular Structures and Organelles, Pathogens, Cellular Types, Public aspects of medicine, RA1-1270, Tyrosine kinase, Research Article, medicine.drug, Cell Binding, Adult, Cell Physiology, Immune Cells, Immunology, 030231 tropical medicine, Microbiology, Spinal Cord Diseases, 03 medical and health sciences, DNA-binding proteins, Retroviruses, Genetics, medicine, Humans, Gene Regulation, Non-coding RNA, Microbial Pathogens, Protein Kinase Inhibitors, Aged, Retrospective Studies, Blood Cells, Biology and life sciences, business.industry, Organisms, Public Health, Environmental and Occupational Health, Proteins, Membrane Proteins, Imatinib, Cell Biology, Htlv-1, medicine.disease, HTLV-I Infections, Regulatory Proteins, 030104 developmental biology, Nilotinib, DNA, Viral, Enzymology, Leukocytes, Mononuclear, Cancer research, RNA, business, Protein Kinases, Transcription Factors, Chronic myelogenous leukemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c2e051e465c13e2f222a9cd5a7e375Test
https://doaj.org/article/45b26dbcd2734f2992430d4f06be1facTest

5

Tumor hepatitis B virus RNA identifies a clinically and molecularly distinct subset of hepatocellular carcinoma

المؤلفون: Huat Chye Lim, John D. Gordan

المصدر: PLoS Computational Biology, Vol 17, Iss 2, p e1008699 (2021)
PLoS Computational Biology

مصطلحات موضوعية: Male, 0301 basic medicine, Nonsynonymous substitution, DNA Repair, Carcinogenesis, medicine.disease_cause, 0302 clinical medicine, Transcription (biology), CDKN2A, Basic Cancer Research, Missense mutation, Biology (General), Pathology and laboratory medicine, Viral Genomics, Principal Component Analysis, Kelch-Like ECH-Associated Protein 1, Ecology, Liver Diseases, Liver Neoplasms, virus diseases, Genomics, Medical microbiology, Middle Aged, Phenotype, Oncology, Computational Theory and Mathematics, 030220 oncology & carcinogenesis, Modeling and Simulation, Viruses, RNA, Viral, Female, Pathogens, Research Article, Adult, Hepatitis B virus, Carcinoma, Hepatocellular, QH301-705.5, Gastroenterology and Hepatology, Microbial Genomics, Biology, Microbiology, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cancer Genomics, Malignant Tumors, Germline mutation, Genomic Medicine, Virology, Cell Line, Tumor, Gastrointestinal Tumors, Biomarkers, Tumor, Genetics, medicine, Humans, Molecular Biology, Gene, Cyclin-Dependent Kinase Inhibitor p16, Ecology, Evolution, Behavior and Systematics, Aged, Proportional Hazards Models, Medicine and health sciences, Biology and life sciences, Carcinoma, Viral pathogens, Organisms, Cancers and Neoplasms, Computational Biology, RNA, Hepatocellular Carcinoma, Hepatitis viruses, digestive system diseases, Microbial pathogens, 030104 developmental biology, Mutation, Cancer research, Somatic Mutation, Tumor Suppressor Protein p53

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a44cb07ed9c1d6ba6cc8b5c415db5e9Test
https://doi.org/10.1371/journal.pcbi.1008699Test

6

Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases

المصدر: PLoS Genetics, Vol 17, Iss 1, p e1009113 (2021)
PLoS Genetics

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Colorectal cancer, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, QH426-470, Immune Receptors, Biochemistry, Metastasis, White Blood Cells, 0302 clinical medicine, Animal Cells, Basic Cancer Research, Medicine and Health Sciences, Cytotoxic T cell, Postoperative Period, Immune Response, Hepatitis A Virus Cellular Receptor 2, Genetics (clinical), Aged, 80 and over, Immune System Proteins, T Cells, Genomics, Middle Aged, Progression-Free Survival, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Cellular Types, Colorectal Neoplasms, Research Article, Signal Transduction, Adenoma, Adult, Evolutionary Immunology, DNA Copy Number Variations, Immune Cells, T cell, Immunology, Receptors, Antigen, T-Cell, Biology, 03 medical and health sciences, Cancer Genomics, Genomic Medicine, Genetics, medicine, Carcinoma, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Aged, Colorectal Cancer, Evolutionary Biology, Blood Cells, Genome, Human, Genetic Drift, T-cell receptor, Immunity, Cancers and Neoplasms, Biology and Life Sciences, Proteins, Cell Biology, medicine.disease, T Cell Receptors, 030104 developmental biology, Metastatic Tumors, Cancer research, Neoplasm Recurrence, Local, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927c482c07abdf21ed1e825a726cf5d1Test
https://doi.org/10.1371/journal.pgen.1009113Test

7

Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes

المؤلفون: Margaret A. Morris, Raghavendra G. Mirmira, Jerry L. Nadler, Ivan C. Gerling, Julius O. Nyalwidhe, Wojciech J. Grzesik, Michele L. Semeraro, Tayab C. Waseem, Tanya C. Burch

المصدر: PLoS ONE, Vol 12, Iss 9, p e0183908 (2017)
PLoS ONE

مصطلحات موضوعية: Male, Proteomics, 0301 basic medicine, endocrine system diseases, Physiology, Protein Expression, lcsh:Medicine, Pancreatitis-Associated Proteins, medicine.disease_cause, Biochemistry, Mass Spectrometry, Autoimmunity, Pathogenesis, Endocrinology, 0302 clinical medicine, Immune Physiology, Medicine and Health Sciences, Insulin, Child, lcsh:Science, Laser capture microdissection, Microscopy, Confocal, Immune System Proteins, Multidisciplinary, 3. Good health, Optical Equipment, 030220 oncology & carcinogenesis, Proteome, Engineering and Technology, Female, Anatomy, Metabolic Networks and Pathways, Research Article, Adult, endocrine system, Endocrine Disorders, Immunology, Equipment, Endocrine System, Laser Capture Microdissection, Biology, Research and Analysis Methods, Antibodies, Islets of Langerhans, Young Adult, 03 medical and health sciences, Exocrine Glands, Diabetes Mellitus, Gene Expression and Vector Techniques, medicine, Humans, Protein Interaction Domains and Motifs, Molecular Biology Techniques, Molecular Biology, Pancreas, Autoantibodies, Diabetic Endocrinology, Molecular Biology Assays and Analysis Techniques, Type 1 diabetes, Lasers, lcsh:R, Autoantibody, Biology and Life Sciences, Proteins, nutritional and metabolic diseases, medicine.disease, Molecular biology, Hormones, Diabetes Mellitus, Type 1, 030104 developmental biology, Microscopy, Fluorescence, Metabolic Disorders, Cancer research, lcsh:Q, Peptides, Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412cabf051c654be3553cc8ce31a48f3Test
http://europepmc.org/articles/PMC5587329?pdf=renderTest

8

ALDH1A1 expression is associated with poor differentiation, 'right-sidedness' and poor survival in human colorectal cancer

المؤلفون: Inne H.M. Borel Rinkes, Lizet M. van der Waals, Onno Kranenburg

المصدر: PLoS ONE, Vol 13, Iss 10, p e0205536 (2018)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Male, Colorectal cancer, Cancer Treatment, Gene Expression, lcsh:Medicine, Metastasis, Cohort Studies, Prostate cancer, 0302 clinical medicine, Medicine and Health Sciences, lcsh:Science, Aged, 80 and over, Multidisciplinary, biology, Liver Neoplasms, Middle Aged, Prognosis, Tumor Resection, Primary tumor, Surgical Oncology, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, Anatomy, Colorectal Neoplasms, Research Article, Adult, Clinical Oncology, Colon, Surgical and Invasive Medical Procedures, Research and Analysis Methods, Aldehyde Dehydrogenase 1 Family, 03 medical and health sciences, Cancer stem cell, Diagnostic Medicine, medicine, Biomarkers, Tumor, Humans, Differentiated Tumors, Immunohistochemistry Techniques, Aged, Colorectal Cancer, Surgical Resection, business.industry, Carcinoma, lcsh:R, Computational Biology, Retinal Dehydrogenase, Cancers and Neoplasms, Biology and Life Sciences, Aldehyde Dehydrogenase, medicine.disease, Microarray Analysis, Survival Analysis, ALDH1A1, Gastrointestinal Tract, Histochemistry and Cytochemistry Techniques, 030104 developmental biology, Metastatic Tumors, Tumor progression, biology.protein, Cancer research, Immunologic Techniques, lcsh:Q, Clinical Medicine, business, Digestive System

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eaac04bc9c7e4e41bc1a115bf53e37Test
http://europepmc.org/articles/PMC6181398?pdf=renderTest

9

Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

المؤلفون: Rainer Claus, Justus Duyster, Marcus Dühren-von-Minden, Christine Dierks, Kathrin Kläsener, Maike Buchner, Kerstin Leberecht, Hassan Jumaa, Fabio Malavasi, Marco Benkisser-Petersen, Arlette Dörffel, Hendrik Veelken, Meike Burger, Katja Zirlik, Michael Reth

المصدر: PLoS ONE, Vol 11, Iss 12, p e0169159 (2016)
PLoS One
PLoS ONE
PLoS ONE, 11(12)

مصطلحات موضوعية: 0301 basic medicine, Male, Cell signaling, B Cells, R406 inhibited, Pyridines, Chronic lymphocytic leukemia, Syk, lcsh:Medicine, Apoptosis, CD38, Signal transduction, ERK signaling cascade, Biochemistry, Receptor tyrosine kinase, Hematologic Cancers and Related Disorders, White Blood Cells, 0302 clinical medicine, Spectrum Analysis Techniques, Animal Cells, Cell Movement, immune system diseases, hemic and lymphatic diseases, Medicine and Health Sciences, Tumor Cells, Cultured, SYK, Post-Translational Modification, Phosphorylation, Ligation Assay, Extracellular Signal-Regulated MAP Kinases, lcsh:Science, Chronic Lymphoblastic Leukemia, Aged, 80 and over, Multidisciplinary, Membrane Glycoproteins, biology, Cell Death, Chemistry, Signaling cascades, hemic and immune systems, Hematology, Middle Aged, Flow Cytometry, Cell Motility, Oncology, Spectrophotometry, Cell Processes, Lymphoblastic Leukemia, Female, Cytophotometry, Cellular Types, Research Article, Adult, Cell Survival, Immune Cells, Immunology, Cell Migration, Research and Analysis Methods, 03 medical and health sciences, Downregulation and upregulation, Leukemias, Oxazines, medicine, Humans, Syk Kinase, ddc:610, SYK, AKT, CD38, R406 inhibited, Antibody-Producing Cells, Molecular Biology Techniques, Protein kinase B, Molecular Biology, neoplasms, Aged, Molecular Biology Assays and Analysis Techniques, Blood Cells, AKT, lcsh:R, Cancers and Neoplasms, Biology and Life Sciences, Proteins, Cell Biology, medicine.disease, ADP-ribosyl Cyclase 1, Leukemia, Lymphocytic, Chronic, B-Cell, Chemokine CXCL12, 030104 developmental biology, biology.protein, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, lcsh:Q, Proto-Oncogene Proteins c-akt, 030215 immunology, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d291812eb97c055e488c3b8b2968ddTest
http://europepmc.org/articles/PMC5201248?pdf=renderTest

10

Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins

المؤلفون: Chih-Wen Shu, Yao-Dung Hsieh, Huei-Cin Sie, Ting-Ying Fu, Liang-Ming Yen, Yaoh-Shiang Lin, Yun-Chung Lin, Yi-Min Wu, Pei-Feng Liu, Bor-Hwang Kang, Luo-Ping Ger, Ju-Hsin Sun, I-Chien Hsieh, Huei-Han Liou, Yu-Kai Tseng

المصدر: PLoS ONE, Vol 12, Iss 6, p e0178581 (2017)
PLoS ONE

مصطلحات موضوعية: Male, 0301 basic medicine, Carcinogenesis, Cellular differentiation, lcsh:Medicine, Vimentin, Pathology and Laboratory Medicine, medicine.disease_cause, Biochemistry, Metastasis, Cytopathology, 0302 clinical medicine, Basic Cancer Research, Medicine and Health Sciences, lcsh:Science, Multidisciplinary, Tissue microarray, biology, Nuclear Proteins, Cell Differentiation, Middle Aged, Cadherins, Prognosis, Tongue Neoplasms, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Immunohistochemistry, Female, Anatomy, Research Article, Adult, Epithelial-Mesenchymal Transition, Lymphatic System, 03 medical and health sciences, Biomarkers, Tumor, Carcinoma, medicine, Humans, Epithelial–mesenchymal transition, Twist-Related Protein 1, lcsh:R, Biology and Life Sciences, Proteins, medicine.disease, Cytoskeletal Proteins, 030104 developmental biology, Anatomical Pathology, biology.protein, Cancer research, lcsh:Q, Snail Family Transcription Factors, Lymph Nodes, Biomarkers, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3defcb90c807513858cb9499a631eaTest
http://europepmc.org/articles/PMC5453552?pdf=renderTest

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