Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer
| العنوان: | Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer |
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| المؤلفون: | Angela Botticella, David Planchard, Caroline Caramella, Eric Deutsch, A. Boros, Antoine Schernberg, Alexandre Escande, Benjamin Besse, Cécile Le Péchoux, Laura Mezquita |
| المصدر: | PLoS ONE, Vol 13, Iss 10, p e0204490 (2018) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Lung Neoplasms, Neutrophils, Leukocytosis, Cancer Treatment, lcsh:Medicine, Gastroenterology, Lung and Intrathoracic Tumors, Metastasis, Cohort Studies, Hematologic Cancers and Related Disorders, Leukocyte Count, White Blood Cells, chemistry.chemical_compound, 0302 clinical medicine, Animal Cells, Carcinoma, Non-Small-Cell Lung, Adenocarcinomas, Basic Cancer Research, Medicine and Health Sciences, Neoplasm Metastasis, lcsh:Science, Aged, 80 and over, education.field_of_study, Multidisciplinary, Pharmaceutics, Chemoradiotherapy, Hematology, Middle Aged, Prognosis, Oncology, 030220 oncology & carcinogenesis, Absolute neutrophil count, Female, Cellular Types, medicine.symptom, Research Article, Adult, Clinical Oncology, medicine.medical_specialty, Immune Cells, Immunology, Population, Adenocarcinoma of Lung, Antineoplastic Agents, Carcinomas, Cancer Chemotherapy, 03 medical and health sciences, Drug Therapy, Internal medicine, Biomarkers, Tumor, medicine, Humans, Chemotherapy, education, Survival analysis, Aged, Neoplasm Staging, Blood Cells, Myeloproliferative Disorders, business.industry, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Induction chemotherapy, Cell Biology, medicine.disease, Survival Analysis, Neutrophilia, Carboplatin, Non-Small Cell Lung Cancer, respiratory tract diseases, 030104 developmental biology, chemistry, lcsh:Q, Clinical Medicine, business, Leukocyte Disorders, Brain metastasis |
| الوصف: | Objective To study the prognostic value of baseline leukocytosis or neutrophiliain two retrospective cohorts of stage III Non-Small Cell Lung Cancer (NSCLC) patients. Materials and methods Clinical records of consecutive previously untreated NSCLC patients in our Institution between June 2001 and September 2016 for stage III NSCLC were collected. The prognostic value of pretreatment leucocyte disorders was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as a leukocyte count or a neutrophil count exceeding 10 and 7 G/L, respectively. Results We identified 238 patients, displaying baseline leukocytosis or neutrophilia in 39% and 40% respectively. Most were diagnosed with adenocarcinoma (48%), and stage IIIB NSCLC (58%). 3-year actuarial overall survival (OS) and progression-free survival (PFS) were 35% and 27% respectively. Local relapses were reported in 100 patients (42%), and distant metastases in 132 patients (55%). In multivariate analysis, leukocytosis, neutrophilia, and induction chemotherapy regimen based on carboplatin/paclitaxel were associated with worse OS and PFS (p |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faddc02715e5ef3e50e83a01ffef8f5Test https://doi.org/10.1371/journal.pone.0204490Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5faddc02715e5ef3e50e83a01ffef8f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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