HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil
| العنوان: | HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil |
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| المؤلفون: | Maria Fernanda Rios Grassi, Graham P. Taylor, Bernardo Galvão-Castro, Ney Boa-Sorte, Mauricio Lima Barreto, Inês Dourado, David Nunes, Maria Glória Teixeira |
| المصدر: | PLoS ONE, Vol 12, Iss 2, p e0171303 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | SPASTIC PARAPARESIS HAM/TSP, Male, RNA viruses, Bacterial Diseases, 0301 basic medicine, Physiology, Human immunodeficiency virus (HIV), lcsh:Medicine, HIV Infections, Pathology and Laboratory Medicine, medicine.disease_cause, Treponematoses, Geographical locations, Immunodeficiency Viruses, Japan, Risk Factors, Odds Ratio, Prevalence, Medicine and Health Sciences, Child, lcsh:Science, Treponema Pallidum, GENERAL-POPULATION, Human T-lymphotropic virus 1, Multidisciplinary, Traditional medicine, Coinfection, T-CELL LEUKEMIA, Sexually Transmitted Diseases, Viral, Hematology, Middle Aged, Bacterial Pathogens, Body Fluids, Multidisciplinary Sciences, Infectious Diseases, Blood, Medical Microbiology, Child, Preschool, Population Surveillance, Viral Pathogens, Viruses, HTLV-I infections, LYMPHOTROPIC VIRUS TYPE-1, Science & Technology - Other Topics, Female, Pathogens, Anatomy, PREGNANT-WOMEN, Brazil, Research Article, Neglected Tropical Diseases, Adult, Asia, Adolescent, General Science & Technology, Urology, 030106 microbiology, Sexually Transmitted Diseases, Viral transmission, INFECTIVE DERMATITIS, Microbiology, Young Adult, 03 medical and health sciences, MD Multidisciplinary, Retroviruses, medicine, Humans, Syphilis, Microbial Pathogens, Science & Technology, Biology and life sciences, Genitourinary Infections, business.industry, Lentivirus, lcsh:R, Infant, Newborn, Organisms, Recem nascido, Infant, HIV, Htlv-1, South America, Tropical Diseases, medicine.disease, HTLV-I Infections, Infant newborn, NORTHEASTERN BRAZIL, Cross-Sectional Studies, Infective dermatitis, RISK-FACTORS, I INFECTION, BAHIA STATE, lcsh:Q, People and places, business, Demography |
| الوصف: | Background: Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown. Objective: To investigate the association of syphilis infection as a proxy for sexual transmission of HTLV-1 infection in the general population of this city. Methods: A cross sectional population-based study was conducted with 3,451 serum samples obtained by a representative simple random sampling. Data on gender, age, income, and years of education were collected by questionnaire and the presence of HTLV, HIV and Treponema pallidum infection was determined by serology. Logistic regression analysis was used to evaluate the independent effect of the potential explanatory variables to HTLV-1 infection and Odds Ratios (OR) and 95% CI were calculated. Results: The majority of studied individuals were female (56.4%), had less than 7 years of education (55.3%) and earned two or less minimum wages (52.0%). The overall prevalence of HTLV-1 was 1.48% (51/3,451; 95% CI: 1.10%– 1.94%), which increased with age. Only three persons younger than 17 (3/958; 0.31%; CI 95% 0.06–0.91) years were infected by HTLV-1. Among the 45 syphilis positives, 12 (26.7%) were HTLV positive, while among 21 HIV positives, only one (4.8%) was HTLV positive. HTLV-1 infection was found to be associated with syphilis infection (ORADJUSTED 36.77; 95% CI 14.96–90.41). Conclusion: The data presented herein indicate that horizontal transmission between adults is the main route of HTLV-1 infection in the general population of Salvador and that this is likely to occur through sexual contact. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6ee1f096c5683e9aa9179dd989b4dcTest https://doi.org/10.1371/journal.pone.0171303Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e6ee1f096c5683e9aa9179dd989b4dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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