نتائج البحث - "cyclin‐dependent kinase 1"

1

Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle

المؤلفون: Scott S. Terhune, Yongwoon Jung, Katie M. Cataldo, Ranjan K. Dash

المصدر: PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 4, p e1007733 (2020)

مصطلحات موضوعية: 0301 basic medicine, Kinase Inhibitors, Cell Cycle Proteins, Biochemistry, Ligases, 0302 clinical medicine, Mitotic cell cycle, Biochemical Simulations, Cell Cycle and Cell Division, Protein Interaction Maps, Biology (General), Post-Translational Modification, Phosphorylation, Enzyme Inhibitors, Ecology, Chromosome Biology, Cell Cycle, Cell cycle, Cadherins, Cell biology, Enzymes, Computational Theory and Mathematics, Cell Processes, Modeling and Simulation, Research Article, QH301-705.5, Cdc20 Proteins, Mitosis, CDC20, Biology, Protein Serine-Threonine Kinases, PLK1, Anaphase-Promoting Complex-Cyclosome, 03 medical and health sciences, Cellular and Molecular Neuroscience, Interaction network, Antigens, CD, Proto-Oncogene Proteins, CDC2 Protein Kinase, Genetics, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Cyclin-dependent kinase 1, Phosphatases, Biology and Life Sciences, Proteins, Computational Biology, Protein Complexes, Cell Biology, Models, Theoretical, Ubiquitin Ligases, Kinetics, 030104 developmental biology, Mitotic exit, Enzymology, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce6c749aa0b182ae14cb31520ff35cbTest
http://europepmc.org/articles/PMC7162553Test

2

Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism

المؤلفون: Karen E. Cosgrove, Karolina Mosinska, Sophie G. Kellaway, Indraneel Banerjee, Melanie Newbould, Zainaba Mohamed, Stephen M. Richardson, Mark J. Dunne, Alexander J. Ryan

المصدر: PLoS ONE
Kellaway, S, Mosinska, K, Mohamed, Z, Ryan, A, Richardson, S, Newbould, M, Banerjee, I, Dunne, M & Cosgrove, K 2019, ' Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism ', P L o S One . https://doi.org/10.1371/journal.pone.0222350Test
PLoS ONE, Vol 14, Iss 9, p e0222350 (2019)

مصطلحات موضوعية: 0301 basic medicine, Alizarin Staining, Biochemistry, 0302 clinical medicine, Endocrinology, Spectrum Analysis Techniques, Medicine and Health Sciences, Group-Specific Staining, Medicine, Insulin, Cell Cycle and Cell Division, Staining, Multidisciplinary, geography.geographical_feature_category, Organic Compounds, Monosaccharides, Cell Staining, Cell cycle, Islet, Flow Cytometry, Chemistry, medicine.anatomical_structure, Cell Processes, Spectrophotometry, 030220 oncology & carcinogenesis, Physical Sciences, Cytophotometry, Stem cell, Anatomy, Pancreas, Research Article, Science, Carbohydrates, Endocrine System, Research and Analysis Methods, 03 medical and health sciences, Exocrine Glands, Diabetic Endocrinology, geography, Cyclin-dependent kinase 1, Cell growth, business.industry, Mesenchymal stem cell, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Cell Biology, medicine.disease, Hormones, Nuclear Staining, 030104 developmental biology, Glucose, Specimen Preparation and Treatment, Congenital hyperinsulinism, Cancer research, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54a06cf01f60faa91c8162d7ee4a9aeTest
http://europepmc.org/articles/PMC6746350Test

3

CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45

المؤلفون: Hsing-Chun Kuo, Kam-Fai Lee, Chih-Chuan Teng, Chien-Heng Shen, Wen-Shih Huang, Ko-Chao Lee, Meng-Chiao Hsieh, Cheng-Yi Huang, Yi-Hung Kuo, Shui-Yi Tung

المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0168989 (2017)

مصطلحات موضوعية: 0301 basic medicine, Cell cycle checkpoint, Cancer Treatment, lcsh:Medicine, Apoptosis, Biochemistry, 0302 clinical medicine, Cell Signaling, Medicine and Health Sciences, p300-CBP Transcription Factors, Cell Cycle and Cell Division, lcsh:Science, Cyclin, Multidisciplinary, Cell Death, Protein Kinase Signaling Cascade, Chemistry, Gadd45, Intracellular Signaling Peptides and Proteins, NF-kappa B, Cell cycle, Signaling Cascades, Nucleic acids, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Quinolines, Colorectal Neoplasms, Research Article, Signal Transduction, Cyclin-Dependent Kinase Inhibitor p21, Programmed cell death, Cell Survival, Antineoplastic Agents, 03 medical and health sciences, Cyclins, Cell Line, Tumor, Genetics, Humans, Cell Cycle Inhibitors, Cell Proliferation, Colorectal Cancer, Cyclin-dependent kinase 1, Cell growth, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, DNA, Cell Cycle Checkpoints, 030104 developmental biology, Cancer research, DNA damage, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8301e65080085d51c0a91aba77a2acTest
http://europepmc.org/articles/PMC5221879Test

4

A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells

المؤلفون: Ye Zhang, Lili Cao, Xiang Zhao, Lijun Zhang

المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161025 (2016)

مصطلحات موضوعية: 0301 basic medicine, Isatin, Cancer Treatment, lcsh:Medicine, Apoptosis, Biochemistry, Chalcone, Tubulin, Bibenzyls, Medicine and Health Sciences, Cell Cycle and Cell Division, Molecular Targeted Therapy, Cyclin B1, lcsh:Science, Wnt Signaling Pathway, Cytoskeleton, Cyclin, Oncogene Proteins, Multidisciplinary, Cell Death, Liver Diseases, Cell Cycle, Liver Neoplasms, Wnt signaling pathway, Hep G2 Cells, Cell cycle, Cell biology, Oncology, Cell Processes, Research Article, Carcinoma, Hepatocellular, Autophagic Cell Death, Antineoplastic Agents, Gastroenterology and Hepatology, Biology, Carcinomas, 03 medical and health sciences, Cyclin D1, Microtubule, Tubulins, Cyclins, Gastrointestinal Tumors, Humans, Protein Structure, Quaternary, Cell Proliferation, Cyclin-dependent kinase 1, Focal Adhesions, lcsh:R, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Cell Biology, Hepatocellular Carcinoma, Cytoskeletal Proteins, 030104 developmental biology, Cancer cell, Vacuoles, lcsh:Q, Paxillin, Protein Multimerization, Septins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec880b675eb50ee19632b9ec6158e6a5Test
http://europepmc.org/articles/PMC4985065Test

5

دورية أكاديمية

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

المؤلفون: Diril M.K., Bisteau X., Kitagawa M., Caldez M.J., Wee S., Gunaratne J., Lee S.H., Kaldis P.

المساهمون: DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20200320

العلاقة: Diril M.K., Bisteau X., Kitagawa M., Caldez M.J., Wee S., Gunaratne J., Lee S.H., Kaldis P. (2016). Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS Genetics 12 (9) : e1006310. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1006310Test; https://scholarbank.nus.edu.sg/handle/10635/165381Test

الإتاحة: https://doi.org/10.1371/journal.pgen.1006310Test
https://scholarbank.nus.edu.sg/handle/10635/165381Test

View record in BASE

النص الكامل

6

Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure

المؤلفون: Clorinda Lori, Antonella Lantella, Roberta Chiaraluce, Alessandra Pasquo, Leila T. Alexander, Valerio Consalvi, Stefan Knapp

المساهمون: Pasquo, A.

المصدر: PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e64824 (2013)

مصطلحات موضوعية: Protein Structure, Protein Folding, Protein Denaturation, Biophysics, lcsh:Medicine, MAP3K7, Biochemistry, Protein Chemistry, Polymorphism, Single Nucleotide, Proto-Oncogene Mas, Protein Structure, Secondary, MAP2K7, Proto-Oncogene Proteins c-pim-1, Catalytic Domain, Neoplasms, hemic and lymphatic diseases, Molecular Cell Biology, Basic Cancer Research, Enzyme Stability, Signaling in Cellular Processes, Humans, Transition Temperature, Urea, c-Raf, Kinase activity, lcsh:Science, Protein kinase A, Biology, Serine/threonine-specific protein kinase, Cyclin-dependent kinase 1, Multidisciplinary, biology, lcsh:R, Cyclin-dependent kinase 2, Proteins, Enzymes, Kinetics, Oncology, Amino Acid Substitution, Enzyme Structure, biology.protein, Medicine, lcsh:Q, Research Article, Signal Transduction, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac82d0c16190d6654673dc810c0e8500Test
https://doi.org/10.1371/journal.pone.0064824Test

7

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

المؤلفون: Walker, RG, Thomson, G, Malone, K, Nowicki, MW, Brown, E, Blake, DG, Turner, NJ, Walkinshaw, MD, Grant, KM, Mottram, JC, Kita, K

المساهمون: Kita, K

المصدر: PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1033 (2011)
PLoS Neglected Tropical Diseases
Walker, R G, Thomson, G, Malone, K, Nowicki, M W, Brown, E, Blake, D G, Turner, N J, Walkinshaw, M D, Grant, K M & Mottram, J C 2011, ' High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase ', PLoS Neglected Tropical Diseases, vol. 5, no. 4, e1033, pp.-. https://doi.org/10.1371/journal.pntd.0001033Test

مصطلحات موضوعية: Protein kinase complex, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Antiprotozoal Agents, Drug Evaluation, Preclinical, Chemical library, Pharmacology, Toxicology and Pharmaceutics(all), Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Parasitic Sensitivity Tests, Cyclin-dependent kinase, Animals, Humans, Leishmania major, Amastigote, Protein Kinase Inhibitors, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Cyclin-dependent kinase 1, Infectious Diseases/Antimicrobials and Drug Resistance, biology, lcsh:Public aspects of medicine, Cyclin-dependent kinase 2, Infectious Diseases/Protozoal Infections, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, biology.organism_classification, Small molecule, Cyclin-Dependent Kinases, High-Throughput Screening Assays, 3. Good health, Cell biology, Infectious Diseases, Infectious Diseases/Neglected Tropical Diseases, Biochemistry, chemistry, Biochemistry/Small Molecule Chemistry, 030220 oncology & carcinogenesis, biology.protein, Research Article, Pharmacology/Drug Development