دورية أكاديمية
Risk factors for colonization and infection by Pseudomonas aeruginosa in patients hospitalized in intensive care units in France
| العنوان: | Risk factors for colonization and infection by Pseudomonas aeruginosa in patients hospitalized in intensive care units in France |
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| المؤلفون: | Hoang, S., Georget, A., Asselineau, J., VENIER, Anne-Gaëlle, Leroyer, Camille, Rogues, Anne-Marie, Thiébaut, Rodolphe |
| المساهمون: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2018 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | SISTM, PharmacoEpi-Drugs, USMR, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | OBJECTIVE: To assess the role of environment, medical care and individual risks factors for P. aeruginosa colonization and infection. STUDY DESIGN AND SETTING: A French multicentric prospective study involved ten ICUs for a five months period. Every adult patient newly hospitalized in ICUs with no P. aeruginosa carriage up to 48 hours after admission was included and weekly screened before discharge or death. Screening swabs were either rectal, sputum or oropharyngeal samples. Hydric environment was also sampled each week. Data on patient clinical features, environmental and device exposures, and antibiotics supports were regularly collected. Multivariate analysis was performed with a multistate model. RESULTS: The overall prevalence of P. aeruginosa carriage was 15.3% (201/1314). Risk factors associated with patient colonization were: use of inactive antibiotics against P. aeruginosa (HR = 1.60 [1.15-2.21] p<0.01), tap water contamination at the entry in the room (HR = 1.66 [1.01-2.27] p<0.05) and mechanical invasive ventilation (HR = 4.70 [2.66-8.31] p<0.0001). Active antibiotics prevented from colonization (HR = 0.67 [0.48-0.93] p = 0.02) and from infection (HR = 0.64 [0.41-1.01] p = 0.05). Interaction between hydric environment antibiotics support was not statistically associated with patient colonization. CONCLUSION: Hydric contamination and antibiotics pressure seem to remain key independent risk factors in P. aeruginosa colonization. These results advocate the need to carry on preventive and targeted interventions toward healthcare associated infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03008120; https://hal.archives-ouvertes.fr/hal-03008120Test; https://hal.archives-ouvertes.fr/hal-03008120/documentTest; https://hal.archives-ouvertes.fr/hal-03008120/file/BPH_PO_2018_Hoang.pdfTest |
| DOI: | 10.1371/journal.pone.0193300 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0193300Test https://hal.archives-ouvertes.fr/hal-03008120Test https://hal.archives-ouvertes.fr/hal-03008120/documentTest https://hal.archives-ouvertes.fr/hal-03008120/file/BPH_PO_2018_Hoang.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6F9B5C42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0193300 |
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