دورية أكاديمية
Race/ethnic differences in the associations of the Framingham risk factors with carotid IMT and cardiovascular events
| العنوان: | Race/ethnic differences in the associations of the Framingham risk factors with carotid IMT and cardiovascular events |
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| المؤلفون: | Gijsberts, Crystel M., Groenewegen, Karlijn A., Hoefer, Imo E., Eijkemans, Marinus J.C., Asselbergs, Folkert W., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline M., Engström, Gunnar, Evans, Greg W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, De Kleijn, Dominique P.V., Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, O'Leary, Daniel H., Pasterkamp, Gerard, Peters, Sanne A.E., Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D.A., Bots, Michiel L., Den Ruijter, Hester M. |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2015 |
| المجموعة: | University of Tromsø: Munin Open Research Archive |
| مصطلحات موضوعية: | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 |
| الوصف: | Background Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and cardiovascular events. Methods We used data from an ongoing individual participant meta-analysis involving 17 populationbased cohorts worldwide. We selected 60,211 participants without cardiovascular disease at baseline with available data on ethnicity (White, Black, Asian or Hispanic). We generated a multivariable linear regression model containing risk factors and ethnicity predicting mean common carotid intima-media thickness (CIMT) and a multivariable Cox regression model predicting myocardial infarction or stroke. For each risk factor we assessed how the association with the preclinical and clinical measures of cardiovascular atherosclerotic disease was affected by ethnicity. Results Ethnicity appeared to significantly modify the associations between risk factors and CIMT and cardiovascular events. The association between age and CIMT was weaker in Blacks and Hispanics. Systolic blood pressure associated more strongly with CIMT in Asians. HDL cholesterol and smoking associated less with CIMT in Blacks. Furthermore, the association of age and total cholesterol levels with the occurrence of cardiovascular events differed between Blacks and Whites. Conclusion The magnitude of associations between risk factors and the presence of atherosclerotic disease differs between race/ethnic groups. These subtle, yet significant differences provide insight in the etiology of cardiovascular disease among race/ethnic groups. These insights aid the race/ethnic-specific implementation of primary prevention. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | PLoS ONE 2015, 10:e013321(7); FRIDAID 1286957; https://hdl.handle.net/10037/8644Test; URN:NBN:no-uit_munin_8243 |
| DOI: | 10.1371/journal.pone.0132321 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0132321Test https://hdl.handle.net/10037/8644Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.7738E765 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0132321 |