نتائج البحث

1

دورية أكاديمية

Non-canonical functions of a mutant TSC2 protein in mitotic division.

المؤلفون: Chalkley, Mary-Bronwen L.¹ (AUTHOR), Mersfelder, Rachel B.¹ (AUTHOR), Sundberg, Maria² (AUTHOR), Armstrong, Laura C.³ (AUTHOR), Sahin, Mustafa² (AUTHOR), Ihrie, Rebecca A.^1,4 (AUTHOR) rebecca.ihrie@vanderbilt.edu, Ess, Kevin C.^1,3 (AUTHOR) rebecca.ihrie@vanderbilt.edu

المصدر: PLoS ONE. 10/4/2023, Vol. 18 Issue 10, p1-12. 12p.

مصطلحات موضوعية: *MUTANT proteins, *TUBEROUS sclerosis, *GENETIC mutation, *DEVELOPMENTAL neurobiology, *HETERODIMERS, *CELL growth

النص الكامل

2

دورية أكاديمية

Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4^DCAF11 E3 ubiquitin ligase complex for targeted protein degradation.

المؤلفون: Wang, Ying, Wei, Tianzi, Zhao, Man, Huang, Aima, Sun, Fan, Chen, Lu, Lin, Risheng, Xie, Yubao, Zhang, Ming, Xu, Shiyu, Sun, Zhihui, Hong, Liang, Wang, Rui, Tian, Ruilin, Li, Guofeng

المصدر: PLoS Biology; 5/20/2024, Vol. 22 Issue 5, p1-20, 20p

مصطلحات موضوعية: PROTEOLYSIS, MOIETIES (Chemistry), BROMODOMAIN-containing proteins, HUNTINGTIN protein, MUTANT proteins, DRUG discovery, UBIQUITIN ligases, OXINDOLES

النص الكامل

3

دورية أكاديمية

Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development.

المؤلفون: Sabalette, Karina B., Campo, Vanina A., Sotelo-Silveira, José R., Smircich, Pablo, De Gaudenzi, Javier G.

المصدر: PLoS Neglected Tropical Diseases; 5/17/2024, Vol. 18 Issue 5, p1-29, 29p

مصطلحات موضوعية: TRYPANOSOMA cruzi, RNA-binding proteins, GENE expression, LIFE cycles (Biology), MUTANT proteins, CONENOSES

النص الكامل

4

دورية أكاديمية

Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay.

المؤلفون: Pappas, Christopher T., Mayfield, Rachel M., Dickerson, Ava E., Mi-Mi, Lei, Gregorio, Carol C.

المصدر: PLoS Genetics; 5/15/2024, Vol. 20 Issue 5, p1-14, 14p

مصطلحات موضوعية: CONNECTIN, CELLULAR control mechanisms, MUTANT proteins, STOP codons, GENE families, MICROFILAMENT proteins, DILATED cardiomyopathy

النص الكامل

5

دورية أكاديمية

Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease.

المؤلفون: Walsh, Daniel J., Rees, Judy R., Mehra, Surabhi, Bourkas, Matthew E. C., Kaczmarczyk, Lech, Stuart, Erica, Jackson, Walker S., Watts, Joel C., Supattapone, Surachai

المصدر: PLoS Pathogens; 4/1/2024, Vol. 20 Issue 4, p1-19, 19p

مصطلحات موضوعية: PRION diseases, GENETIC disorders, CREUTZFELDT-Jakob disease, BRAIN diseases, MUTANT proteins

النص الكامل

6

دورية أكاديمية

An ancient bacterial zinc acquisition system identified from a cyanobacterial exoproteome.

المؤلفون: Sarasa-Buisan, Cristina, Ochoa de Alda, Jesús A. G., Velázquez-Suárez, Cristina, Rubio, Miguel Ángel, Gómez-Baena, Guadalupe, Fillat, María F., Luque, Ignacio

المصدر: PLoS Biology; 3/11/2024, Vol. 22 Issue 3, p1-33, 33p

مصطلحات موضوعية: PROTEIN structure prediction, ZINC, SEQUENCE alignment, MUTANT proteins

النص الكامل

7

دورية أكاديمية

Correction: The replication initiator protein of a geminivirus interacts with host monoubiquitination machinery and stimulates transcription of the viral genome.

المؤلفون: Kushwaha, Nirbhay Kumar, Bhardwaj, Mansi, Chakraborty, Supriya

المصدر: PLoS Pathogens; 2/22/2024, Vol. 20 Issue 2, p1-5, 5p

مصطلحات موضوعية: VIRAL genomes, PROTEINS, MUTANT proteins, TRANSGENIC organisms, VIRAL DNA

النص الكامل

8

دورية أكاديمية

Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate.

المؤلفون: Inouye, Satoshi¹ (AUTHOR) sinouye@jnc-corp.co.jp, Sato, Jun-ichi¹ (AUTHOR), Sahara-Miura, Yuiko¹ (AUTHOR), Tomabechi, Yuri² (AUTHOR), Sumida, Yuto³ (AUTHOR), Sekine, Shun-ichi⁴ (AUTHOR), Shirouzu, Mikako² (AUTHOR), Hosoya, Takamitsu^3,5 (AUTHOR)

المصدر: PLoS ONE. 9/21/2022, Vol. 17 Issue 9, p1-24. 24p.

مصطلحات موضوعية: *MUTANT proteins, *LUCIFERASES, *AMINO acid residues, *LUMINESCENCE

النص الكامل

9

دورية أكاديمية

Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity.

المؤلفون: Grunchec, Héloïse¹ (AUTHOR), Deraze, Jérôme¹ (AUTHOR), Dardalhon-Cuménal, Delphine¹ (AUTHOR), Ribeiro, Valérie¹ (AUTHOR), Coléno-Costes, Anne¹ (AUTHOR), Dias, Karine² (AUTHOR), Bloyer, Sébastien³ (AUTHOR), Mouchel-Vielh, Emmanuèle¹ (AUTHOR), Peronnet, Frédérique¹ (AUTHOR) frederique.peronnet@sorbonne-universite.fr, Thomassin, Hélène¹ (AUTHOR) frederique.peronnet@sorbonne-universite.fr

المصدر: PLoS ONE. 8/18/2022, Vol. 17 Issue 8, p1-23. 23p.

مصطلحات موضوعية: *RNA polymerase II, *MUTANT proteins, *IMAGINAL disks, *TRANSCRIPTION factors, *DROSOPHILA melanogaster, *RIBOSOMAL proteins, *GENETIC transcription regulation

النص الكامل

10

دورية أكاديمية

A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

المؤلفون: Ohshima, Tomohito, Jiajun, Zhang, Fukamachi, Takuki, Ohno, Yuko, Senoo, Hiroko, Matsuo, Yasuhiro, Kawamukai, Makoto

المصدر: PLoS ONE; 10/3/2023, Vol. 18 Issue 10, p1-22, 22p

مصطلحات موضوعية: SEX differentiation (Embryology), SCHIZOSACCHAROMYCES pombe, CARRIER proteins, RNA-binding proteins, MUTANT proteins

النص الكامل

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