Paternally Expressed, Imprinted Insulin-Like Growth Factor-2 in Chorionic Villi Correlates Significantly with Birth Weight
| العنوان: | Paternally Expressed, Imprinted Insulin-Like Growth Factor-2 in Chorionic Villi Correlates Significantly with Birth Weight |
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| المؤلفون: | Charalambos Demetriou, Sayeda Abu-Amero, Anna C Thomas, Miho Ishida, Reena Aggarwal, Lara Al-Olabi, Lydia J Leon, Jaime L Stafford, Argyro Syngelaki, Donald Peebles, Kypros H Nicolaides, Lesley Regan, Philip Stanier, Gudrun E Moore |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 1, p e85454 (2014) |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Anatomy and Physiology, General Science & Technology, lcsh:Medicine, Gene Expression, PHLDA2 GENE, Endocrine System, Real-Time Polymerase Chain Reaction, Pediatrics, Genomic Imprinting, Insulin-Like Growth Factor II, FOR-GESTATIONAL-AGE, MD Multidisciplinary, Genetics, Birth Weight, Humans, Growth Retardation, PLACENTAL EXPRESSION, Statistical Methods, lcsh:Science, Biology, CORD-BLOOD, Insulin-like Growth Factor, DNA Primers, Science & Technology, IGF-I RECEPTOR, Endocrine Physiology, Base Sequence, NEWBORNS, Reverse Transcriptase Polymerase Chain Reaction, lcsh:R, Statistics, Human Genetics, INTRAUTERINE, Multidisciplinary Sciences, Science & Technology - Other Topics, FETAL-GROWTH, Medicine, lcsh:Q, Neonatology, Chorionic Villi, RETARDATION, RESTRICTION, Mathematics, Research Article, Developmental Biology |
| الوصف: | Context: Fetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormone that is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term tissues. Conversely the maternally expressed growth suppressor, PHLDA2, has a significant negative correlation between its term placental expression and birth weight. Objective: The aim of this study is to address the role in early gestation of expression of IGF1, IGF2, their receptors IGF1R and IGF2R, and PHLDA2 on term birth weight. Design: Real-time quantitative PCR was used to investigate mRNA expression of IGF1, IGF2, IGF1R, IGF2R and PHLDA2 in chorionic villus samples (CVS) (n = 260) collected at 11–13 weeks’ gestation. Expression was correlated with term birth weight using statistical package R including correction for several confounding factors. Results: Transcript levels of IGF2 and IGF2R revealed a significant positive correlation with birth weight (0.009 and 0.04, respectively). No effect was observed for IGF1, IGF1R or PHLDA2 and birth weight. Critically, small for gestational age (SGA) neonates had significantly lower IGF2 levels than appropriate for gestational age neonates (p = 3?661027 ). Interpretation: Our findings show that IGF2 mRNA levels at 12 weeks gestation could provide a useful predictor of future fetal growth to term, potentially predicting SGA babies. SGA babies are known to be at a higher risk for type 2 diabetes. This research reveals an imprinted, parentally driven rheostat for in utero growth. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5442cf007cd050f63d1a3b44ee12d6c6Test http://europepmc.org/articles/PMC3893199Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....5442cf007cd050f63d1a3b44ee12d6c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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