التفاصيل البيبلوغرافية
| العنوان: |
Risk of liver fibrosis in patients with prediabetes and diabetes mellitus. |
| المؤلفون: |
Park, Jongsin1 (AUTHOR), Kwon, Heon-Ju2 (AUTHOR), Sohn, Won1 (AUTHOR) wonsohn1@gmail.com, Cho, Ju-Yeon3 (AUTHOR), Park, Soo Jin4 (AUTHOR), Chang, Yoosoo5,6,7 (AUTHOR), Ryu, Seungho5,6,7 (AUTHOR), Kim, Byung Ik1 (AUTHOR), Cho, Yong Kyun1 (AUTHOR) |
| المصدر: |
PLoS ONE. 6/2/2022, Vol. 17 Issue 6, p1-14. 14p. |
| مصطلحات موضوعية: |
*HEPATIC fibrosis, *DIABETES, *GLUCOSE intolerance, *PEOPLE with diabetes, *PREDIABETIC state |
| مستخلص: |
The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimensional real-time MRE. The risk of significant liver fibrosis was compared among three groups. A total of 2,090 subjects were included: no glucose intolerance (n = 889); prediabetes (n = 985); and diabetes (n = 216). Mean values of LSM in those with no glucose intolerance, prediabetes, and diabetes were 2.37 ± 0.43 kPa, 2.41 ± 0.34 kPa, and 2.65 ± 0.70 kPa, respectively (p<0.001). Proportions of significant fibrosis (LSM ≥2.97 kPa) in no glucose intolerance, prediabetes, and diabetes groups were 3.1%, 4.4%, and 16.7%, respectively (p<0.001). Compared with those with no glucose intolerance, those with diabetes had higher risk of significant fibrosis (adjusted odds ratio [aOR]: 3.02, 95% confidence interval [CI]: 1.57–5.81, p<0.001). However, there was no difference between prediabetes and no glucose intolerance (aOR: 1.05, 95% CI: 0.59–1.86, p = 0.876). A subgroup analysis also showed that prediabetes, unlike diabetes, was not associated with significant fibrosis in subjects with or without liver disease. Diabetes, but not prediabetes, is a risk factor for significant liver fibrosis. This finding is consistent regarldess of the pressence of liver disease. [ABSTRACT FROM AUTHOR] |
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