التفاصيل البيبلوغرافية
| العنوان: |
The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes. |
| المؤلفون: |
Lundberg, Marcus, Lindqvist, Andreas, Wierup, Nils, Krogvold, Lars, Dahl-Jørgensen, Knut, Skog, Oskar |
| المصدر: |
PLoS ONE; 6/19/2017, Vol. 12 Issue 6, p1-10, 10p |
| مصطلحات موضوعية: |
TYPE 1 diabetes, PANCREATIC innervation, PARASYMPATHETIC nervous system, EXOCRINE pancreatic insufficiency, AXONS, DISEASES, DIAGNOSIS |
| مستخلص: |
To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in individuals with recent onset type 1 diabetes. The reduced density of parasympathetic axons in the exocrine compartment could have functional implications, e.g. be related to the exocrine insufficiency reported in type 1 diabetes patients. Further studies are needed to understand whether reduced parasympathetic innervation is a cause or consequence of type 1 diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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