دورية أكاديمية
Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model
| العنوان: | Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model |
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| المؤلفون: | Åm, Marte Kierulf, Kölle, Konstanze, Fougner, Anders Lyngvi, Dirnena-Fusini, Ilze, Bösch, Patrick Christian, Ellingsen, Reinold, Hjelme, Dag Roar, Stavdahl, Øyvind, Carlsen, Sven Magnus, Christiansen, Sverre |
| المصدر: | 1-21 ; 13:e0205447 ; PLoS ONE ; 10 |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2018 |
| المجموعة: | NTNU Open Archive (Norges teknisk-naturvitenskapelige universitet / Norwegian University of Science and Technology) |
| مصطلحات موضوعية: | Glukosemåling, Glucose sensing, Diabetes, Kunstig bukspyttkjertel, Artificial Pancreas, VDP::Medisinske fag: 700, VDP::Midical sciences: 700 |
| الوصف: | In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable glucose sensing. However, subcutaneous continuous glucose monitoring carries the disadvantage of slow dynamics. As an alternative, we explored continuous glucose sensing in the peritoneal space, and investigated potential spatial differences in glucose dynamics within the peritoneal cavity. As a secondary outcome, we compared the glucose dynamics in the peritoneal space to the subcutaneous tissue. Material and methods: Eight-hour experiments were conducted on 12 anesthetised non-diabetic pigs. Four commercially available amperometric glucose sensors (FreeStyle Libre, Abbott Diabetes Care Ltd., Witney, UK) were inserted in four different locations of the peritoneal cavity and two sensors were inserted in the subcutaneous tissue. Meals were simulated by intravenous infusions of glucose, and frequent arterial blood and intraperitoneal fluid samples were collected for glucose reference. Results: No significant differences were discovered in glucose dynamics between the four quadrants of the peritoneal cavity. The intraperitoneal sensors responded faster to the glucose excursions than the subcutaneous sensors, and the time delay was significantly smaller for the intraperitoneal sensors, but we did not find significant results when comparing the other dynamic parameters. ; publishedVersion ; © 2018 Åm et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doi.org/10.1371/journal.pone.0205447Test; Norges forskningsråd: 248872; Samarbeidsorganet mellom Helse Midt-Norge og NTNU: 2014/23166; PLoS ONE. 2018, 13:e0205447 (10), 1-21.; urn:issn:1932-6203; http://hdl.handle.net/11250/2592136Test; cristin:1615744 |
| DOI: | 10.1371/journal.pone.0205447 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0205447Test http://hdl.handle.net/11250/2592136Test |
| حقوق: | Navngivelse 4.0 Internasjonal ; http://creativecommons.org/licenses/by/4.0/deed.noTest |
| رقم الانضمام: | edsbas.1FF04678 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0205447 |