Quantifying the Improvement of Surrogate Indices of Hepatic Insulin Resistance Using Complex Measurement Techniques
| العنوان: | Quantifying the Improvement of Surrogate Indices of Hepatic Insulin Resistance Using Complex Measurement Techniques |
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| المؤلفون: | Michael Khan, Martin A. Osterhoff, Matthias Möhlig, Ayman M. Arafat, Andreas Pfeiffer, Peter Nowotny, Michael Roden, Jürgen Machann, Martin O. Weickert, John Hattersley, Johannes Hierholzer, Christian von Loeffelholz |
| المصدر: | PLoS ONE BASE-Bielefeld Academic Search Engine PLoS ONE, Vol 7, Iss 6, p e39029 (2012) |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Blood Glucose, Male, Epidemiology, lcsh:Medicine, Overweight, Body Mass Index, Endocrinology, Statistics, Insulin, Longitudinal Studies, lcsh:Science, QA, Epidemiological Methods, Metabolic Syndrome, Glucose tolerance test, Multidisciplinary, medicine.diagnostic_test, Fasting, Glucose clamp technique, Middle Aged, Regression, Liver, Medicine, Female, medicine.symptom, Research Article, medicine.medical_specialty, Insulin resistance, Internal medicine, Linear regression, medicine, Humans, Obesity, Nutrition, Diabetic Endocrinology, Endocrine Physiology, business.industry, lcsh:R, Diabetes Mellitus Type 2, Glucose Tolerance Test, medicine.disease, R1, Hormones, Biomarker Epidemiology, Glucose Clamp Technique, lcsh:Q, Metabolic syndrome, Insulin Resistance, business, Body mass index, Mathematics, Biomarkers |
| الوصف: | We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR). Five indices, one previously defined and four newly generated through step-wise linear regression, were created against a single-cohort sample of 77 extensively characterised participants with the metabolic syndrome (age 55.6 ± 1.0 years, BMI 31.5 ± 0.4 kg/m(2); 30 males). HEP-IR was defined by measuring endogenous-glucose-production (EGP) with [6-6(2)H(2)] glucose during fasting and euglycemic-hyperinsulinemic clamps and expressed as EGP*fasting plasma insulin. Complex measures were incorporated into the model, including various non-standard biomarkers and the measurement of body-fat distribution and liver-fat, to further improve the predictive capability of the index. Validation was performed against a data set of the same subjects after an isoenergetic dietary intervention (4 arms, diets varying in protein and fiber content versus control). All five indices produced comparable prediction of HEP-IR, explaining 39-56% of the variance, depending on regression variable combination. The validation of the regression equations showed little variation between the different proposed indices (r(2) = 27-32%) on a matched dataset. New complex indices encompassing advanced measurement techniques offered an improved correlation (r = 0.75, P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f29cdb399157aef81b428a11f9c1cf7Test http://europepmc.org/articles/PMC3382235Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3f29cdb399157aef81b428a11f9c1cf7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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