التفاصيل البيبلوغرافية
| العنوان: |
Predictors of Beta-Blocker Intolerance and Mortality in Patients After Acute Coronary Syndrome. |
| المؤلفون: |
De Stefano, Laercio Martins, Ferraz, Alex Lombardi Barbosa, Ferreira, Ana Lúcia dos Anjos, Gut, Ana Lúcia, Cogni, Ana Lúcia, Farah, Elaine, Matsubara, Beatriz Bojikian |
| المصدر: |
PLoS ONE; Oct2013, Vol. 8 Issue 10, p1-1, 1p |
| مصطلحات موضوعية: |
ADRENERGIC beta blockers, HOSPITAL mortality, ACUTE coronary syndrome, HEART disease related mortality, DEATH rate, HOSPITAL admission & discharge, REGRESSION analysis |
| مستخلص: |
Purpose:To investigate the predictors of intolerance to beta-blockers treatment and the 6-month mortality in hospitalized patients with acute coronary syndrome (ACS). Methods:This was a single-center, prospective, and longitudinal study including 370 consecutive ACS patients in Killip class I or II. BBs were prescribed according to international guidelines and withdrawn if intolerance occurred. The study was approved by the institutional ethics committee of our university. Statistics: the clinical parameters evaluated at admission, and the related intolerance to BBs and death at 6 months were analyzed using logistic regression (p<0.05)in PATIENTS. Results:BB intolerance was observed in 84 patients and was associated with no prior use of statins (OR: 2.16, 95%CI: 1.26–3.69, p= 0.005) and Killip class II (OR: 2.5, 95%CI: 1.30-4.75, p=0.004) in the model adjusted for age, sex, blood pressure, and renal function. There was no association with ST-segment alteration or left anterior descending coronary artery plaque. Intolerance to BB was associated with the greatest risk of death (OR: 4.5, 95%CI: 2.15–9.40, p<0.001). Conclusions:After ACS, intolerance to BBs in the first 48 h of admission was associated to non previous use of statin and Killip class II and had a high risk of death within 6 months. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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