التفاصيل البيبلوغرافية
| العنوان: |
Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response. |
| المؤلفون: |
Bedke, Nicole, Sammut, David, Green, Ben, Kehagia, Valia, Dennison, Patrick, Jenkins, Gisli, Tatler, Amanda, Howarth, Peter H., Holgate, Stephen T., Davies, Donna E. |
| المصدر: |
PLoS ONE; Sep2012, Vol. 7 Issue 9, Special section p1-13, 13p |
| مصطلحات موضوعية: |
RHINOVIRUSES, INFECTION, ASTHMA, IMMUNE response, EPITHELIAL cells, OBSTRUCTIVE lung diseases |
| مستخلص: |
Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-β, influences interferon (IFN) production by primary bronchial epithelial cells (PBECs) following RV infection. Exogenous TGF-β2 increased RV replication and decreased IFN protein secretion in response to RV or double-stranded RNA (dsRNA). Conversely, neutralizing TGF-β antibodies decreased RV replication and increased IFN expression in response to RV or dsRNA. Endogenous TGF-β2 levels were higher in conditioned media of PBECs from asthmatic donors and the suppressive effect of anti-TGF-β on RV replication was significantly greater in these cells. Basal SMAD-2 activation was reduced when asthmatic PBECs were treated with anti-TGFβ and this was accompanied by suppression of SOCS-1 and SOCS-3 expression. Our results suggest that endogenous TGFβ contributes to a suppressed IFN response to RV infection possibly via SOCS-1 and SOCS-3. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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