التفاصيل البيبلوغرافية
| العنوان: |
A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication. |
| المؤلفون: |
Osumi, Hiroki1, Fujisaki, Junko1 junko.fujisaki@jfcr.or.jp, Suganuma, Takanori2, Horiuchi, Yusuke1, Omae, Masami1, Yoshio, Toshiyuki1, Ishiyama, Akiyoshi1, Tsuchida, Tomohiro1, Miki, Kazumasa1 |
| المصدر: |
PLoS ONE. 8/30/2017, Vol. 12 Issue 8, p1-9. 9p. |
| مصطلحات موضوعية: |
*PEPSINOGEN, *HELICOBACTER, *GRAM-negative bacteria, *HELICOBACTER pylori, *GASTRIC juice |
| مستخلص: |
Background: Helicobacter pylori (H. pylori) eradication is usually assessed using the 13C-urea breath test (UBT), anti-H. pylori antibody and the H. pylori stool antigen test. However, a few reports have used pepsinogen (PG), in particular, the percentage change in the PG I/II ratio. Here, we evaluated the usefulness of the percentage changes in serum PG I/II ratios for determining the success of eradication therapy for H. pylori. Materials and methods: In total, 650 patients received eradication therapy from October 2008 to March 2013 in our Cancer Institute Hospital. We evaluated the relationship between H. pylori eradication and percentage changes in serum PG I/II ratios before and 3 months after treatment with CLEIA® (FUJIREBIO Inc, Tokyo, Japan). The gold standard of H. pylori eradication was defined as negative by the UBT performed 3 months after completion of eradication treatment. Cut-off values for percentage changes in serum PG I/II ratios were set as +40, +25 and +10% when the serum PG I/II ratio before treatment was below 3.0, above 3.0 but below 5.0 and 5.0 or above, respectively. Results: Serum PG I and PG II levels were measured in 562 patients with H. pylori infection before and after eradication therapy. Eradication of H. pylori was achieved in 433 patients studied (77.0%). The ratios of first, second, third-line and penicillin allergy eradication treatment were 73.8% (317/429), 88.3% (99/112), 75% (12/16) and 100% (5/5), respectively. An increasing percentage in the serum levels of the PG I/II ratios after treatment compared with the values before treatment clearly distinguished success from failure of eradication (108.2±57.2 vs. 6.8±30.7, p<0.05). Using the above cut-off values, the sensitivity, specificity and validity for determination of H. pylori were 93.1, 93.8 and 93.2%, respectively. Conclusion: In conclusion, the percentage changes in serum PG I/II ratios are useful as evaluation criteria for assessing the success of eradication therapy for H. pylori. [ABSTRACT FROM AUTHOR] |
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