التفاصيل البيبلوغرافية
| العنوان: |
Clinicopathologic Predictors of Survival in Patients with Desmoplastic Melanoma. |
| المؤلفون: |
Han, Dale, Han, Gang, Zhao, Xiuhua, Rao, Nikhil G., Messina, Jane L., Marzban, Suroosh S., Sarnaik, Amod A., Cruse, C. Wayne, Sondak, Vernon K., Zager, Jonathan S. |
| المصدر: |
PLoS ONE; Mar2015, Vol. 10 Issue 3, p1-12, 12p |
| مصطلحات موضوعية: |
CLINICAL trials, RETROSPECTIVE studies, HEALTH outcome assessment, HISTOPATHOLOGY, MULTIVARIATE analysis |
| مستخلص: |
Background and Objectives: Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival. We sought to identify melanoma-specific factors influencing survival in patients with desmoplastic melanoma. Methods: Retrospective review from 1993 to 2011 identified 316 patients with primary desmoplastic melanoma. Clinicopathologic characteristics were correlated with nodal status and outcome. Results: Fifty-five patients (17.4%) had nodal disease: 33 had a positive sentinel lymph node biopsy and 22 developed nodal recurrences (no sentinel lymph node biopsy or false-negative sentinel lymph node biopsy). Nodal disease occurred more often in younger patients and in cases with mixed compared with pure histology (26.7% vs. 14.6%); both of these variables significantly predicted nodal status on multivariable analysis (p<0.05). After a median follow-up of 5.3 years, recurrence developed in 87 patients (27.5%), and 111 deaths occurred. The cause of death was known in 79 cases, with 47 deaths (59.5%) being melanoma-related. On multivariable analysis, Breslow thickness, mitotic rate ≥1/mm2 and nodal status significantly predicted melanoma-specific survival (p<0.05). Conclusions: Nodal status predicts melanoma-specific survival in patients with desmoplastic melanoma. However, since patients with desmoplastic melanoma represent an older population, and a considerable proportion of deaths are not melanoma-related (40.5%), comorbidities should be carefully considered in making staging and treatment decisions in this population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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