التفاصيل البيبلوغرافية
| العنوان: |
Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin. |
| المؤلفون: |
Yang, Sunggu, Govindaiah, Gubbi, Lee, Sang-Hun, Yang, Sungchil, Cox, Charles L. |
| المصدر: |
PLoS ONE; 12/18/2017, Vol. 12 Issue 12, p1-12, 12p |
| مصطلحات موضوعية: |
THALAMOCORTICAL system, DENDRITIC cells, AXONS, VISUAL cortex, INTERNEURONS, NEUROPHYSIOLOGY, GABAERGIC neurons |
| مستخلص: |
Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals. [ABSTRACT FROM AUTHOR] |
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