التفاصيل البيبلوغرافية
| العنوان: |
Allografts of the Acellular Sciatic Nerve and BrainDerived Neurotrophic Factor Repair Spinal Cord Injury in Adult Rats. |
| المؤلفون: |
Changyu Li1, Xiangtong Zhang1, Ronglong Cao1, Bohai Yu2, Hongsheng Liang1, Min Zhou3, Dayong Li4, Yuehua Wang1, Enzhong Liu1 enzhongliu@163.com, Kline, Anthony E.5 |
| المصدر: |
PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-7. 7p. |
| مصطلحات موضوعية: |
*GROWTH factors, *SCAFFOLD proteins, *SCIATIC nerve, *NEUROTROPHINS, *AXONS, *REGENERATION (Biology) |
| مستخلص: |
Objective: We aimed to investigate whether an innovative growth factor- laden scaffold composed of acellular sciatic nerve (ASN) and brain-derived neurotrophic factor (BDNF) could promote axonal regeneration and functional recovery after spinal cord injury (SCI). Methods: Following complete transection at the thoracic level (T9), we immediately transplanted the grafts between the stumps of the severed spinal cords. We evaluated the functional recovery of the hindlimbs of the operated rats using the BBB locomotor rating scale system every week. Eight weeks after surgery, axonal regeneration was examined using the fluorogold (FG) retrograde tracing method. Electrophysiological analysis was carried out to evaluate the improvement in the neuronal circuits. Immunohistochemistry was employed to identify local injuries and recovery. Results: The results of the Basso-Beattie-Bresnahan (BBB) scale indicated that there was no significant difference between the individual groups. The FG retrograde tracing and electrophysiological analyses indicated that the transplantation of ASN-BDNF provided a permissive environment to support neuron regeneration. Conclusion: The ASN-BDNF transplantation provided a promising therapeutic approach to promote axonal regeneration and recovery after SCI, and can be used as part of a combinatory treatment strategy for SCI management. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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