Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children
| العنوان: | Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children |
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| المؤلفون: | Shang Han Yang, Kai Wei Liao, Betau Hwang, Jung Chieh Du, Ming Yi Chung, Mei-Lien Chen, Ching Jung Yu, Hsien Chih Chiou, Ling Chu Chien, Winnie Yang |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 2, p e0149558 (2016) |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Physiology, Dopamine, lcsh:Medicine, Social Sciences, 010501 environmental sciences, Urine, Bioinformatics, 01 natural sciences, Biochemistry, Nervous System, chemistry.chemical_compound, Families, 0302 clinical medicine, Catecholamines, Mathematical and Statistical Techniques, Sociology, Epidemiology, Medicine and Health Sciences, Odds Ratio, Amines, lcsh:Science, Child, Children, Multidisciplinary, Organic Compounds, Dopaminergic, Neurochemistry, Environmental exposure, Neurotransmitters, Body Fluids, Chemistry, Neurology, Creatinine, Child, Preschool, Physical Sciences, Regression Analysis, Female, Animal studies, Anatomy, Statistics (Mathematics), Research Article, medicine.medical_specialty, Biogenic Amines, Adolescent, Taiwan, Neuropsychiatric Disorders, Research and Analysis Methods, Polymorphism, Single Nucleotide, Education, 03 medical and health sciences, Developmental Neuroscience, Phenols, Mental Health and Psychiatry, medicine, Attention deficit hyperactivity disorder, Humans, Statistical Methods, Psychiatry, Educational Attainment, 0105 earth and related environmental sciences, Demography, business.industry, lcsh:R, Organic Chemistry, Case-control study, Chemical Compounds, Biology and Life Sciences, Genetic Variation, Odds ratio, Environmental Exposure, medicine.disease, Hormones, Nonylphenol, chemistry, Lead, Neurodevelopmental Disorders, Age Groups, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, People and Places, lcsh:Q, Adhd, Population Groupings, business, 030217 neurology & neurosurgery, Biomarkers, Mathematics, Neuroscience |
| الوصف: | OBJECTIVE:Nonylphenol (NP) belongs to the family of endocrine disruptors, and it is widely used in industrial applications and is ubiquitous in daily foods. Animal studies have suggested that NP exposure might promote motor hyperactivity, likely by causing deficits in dopaminergic neurons. However, research assessing NP exposure and epidemiology studies on human populations are limited. The aim of this study was to explore the association between child NP exposure and ADHD while considering particular covariants, such as lead levels and dopamine-related gene variations. METHODS:A case-control study was conducted on patients with clinically diagnosed ADHD; the Swanson, Nolan and Pelham, Fourth Revision (SNAP-IV) questionnaire was used to identify normal controls aged 4-15 years. Participants were examined for urinary NP concentrations, blood lead levels, and select single-nucleotide polymorphisms of two dopamine-related genes (D4 dopamine receptor, DRD4, and dopamine transporter, DAT1). Socio-demographic variables, maternal lifestyle factors during pregnancy and family medical history were obtained using a questionnaire. RESULTS:A total of 97 children with doctor-diagnosed ADHD and 110 normal controls were enrolled. The blood lead levels in both groups were similar (1.57±0.73 vs. 1.73±0.77 μg/dL, p = 0.15). No significant difference in urinary NP concentration was found between the children with ADHD and the control subjects (4.52±3.22 μg/g cr. vs. 4.64±2.95 μg/g cr., p = 0.43). ADHD was significantly more prevalent among males in this study (male to female ratio: 5:1 for the ADHD group and 1.3:1 for the control group, p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135153074fa6d93c6c4f192d350ed915Test http://europepmc.org/articles/PMC4758720Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....135153074fa6d93c6c4f192d350ed915 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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