Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain
| العنوان: | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain |
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| المؤلفون: | Monica H. T. Wong, Claus Holst, Arne Astrup, Teodora Handjieva-Darlenska, Susan A. Jebb, Anthony Kafatos, Marie Kunesova, Thomas M. Larsen, J. Alfredo Martinez, Andreas F. H. Pfeiffer, Marleen A. van Baak, Wim H. M. Saris, Paul D. McNicholas, David M. Mutch, on behalf of DiOGenes |
| المساهمون: | Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome |
| المصدر: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname PLoS ONE, Vol 7, Iss 8, p e42858 (2012) PLOS ONE, 7(8):42858. Public Library of Science PLoS ONE |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Low protein, Anatomy and Physiology, medicine.medical_treatment, lcsh:Medicine, Weight Gain, Body Mass Index, Cohort Studies, Endocrinology, Weight loss, Glycemic index, Insulin, PREDICTORS, lcsh:Science, Multidisciplinary, Anthropometry, WOMEN, MEN, Middle Aged, Body Composition, Regression Analysis, Medicine, DIETS, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Diet, Reducing, Clinical Research Design, LONG-TERM, Caloric restriction, LOSS MAINTENANCE, Sex Factors, Internal medicine, Weight Loss, medicine, Humans, Clinical Trials, Obesity, Biology, LOW-PROTEIN, Caloric Restriction, Nutrition, Endocrine Physiology, business.industry, Body Weight, lcsh:R, Body weight, medicine.disease, ENERGY-INTAKE, GLYCEMIC INDEX, lcsh:Q, business, Physiological Processes, Energy Metabolism, Body mass index, Weight gain, RESISTANCE |
| الوصف: | BACKGROUND: Successful weight maintenance following weight loss is challenging for many people. Identifying predictors of longer-term success will help target clinical resources more effectively. To date, focus has been predominantly on the identification of predictors of weight loss. The goal of the current study was to determine if changes in anthropometric and clinical parameters during acute weight loss are associated with subsequent weight regain. METHODOLOGY: The study consisted of an 8-week low calorie diet (LCD) followed by a 6-month weight maintenance phase. Anthropometric and clinical parameters were analyzed before and after the LCD in the 285 participants (112 men, 173 women) who regained weight during the weight maintenance phase. Mixed model ANOVA, Spearman correlation, and linear regression were used to study the relationships between clinical measurements and weight regain. PRINCIPAL FINDINGS: Gender differences were observed for body weight and several clinical parameters at both baseline and during the LCD-induced weight loss phase. LCD-induced changes in BMI (Spearman's ρ = 0.22, p = 0.0002) were inversely associated with weight regain in both men and women. LCD-induced changes in fasting insulin (ρ = 0.18, p = 0.0043) and HOMA-IR (ρ = 0.19, p = 0.0023) were also associated independently with weight regain in both genders. The aforementioned associations remained statistically significant in regression models taking account of variables known to independently influence body weight. CONCLUSIONS/SIGNIFICANCE: LCD-induced changes in BMI, fasting insulin, and HOMA-IR are inversely associated with weight regain in the 6-month period following weight loss. |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4268f9a8dac50d88e7fcdbd08c5056e5Test https://hdl.handle.net/10171/28215Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4268f9a8dac50d88e7fcdbd08c5056e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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