Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation
| العنوان: | Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation |
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| المؤلفون: | Muriel Hannon, Frédéric Baron, Loïc Delens, Coline Daulne, Sophie Servais, Stephanie Humblet-Baron, Evelyne Willems, Yves Beguin, André Gothot, Catherine Menten-Dedoyart, Laurence Seidel |
| المصدر: | PLoS ONE PLoS ONE, Vol 10, Iss 6, p e0130026 (2015) |
| بيانات النشر: | Public Library of Science, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Transplantation Conditioning, Globulin, Adolescent, T cell, T-Lymphocytes, Cell, lcsh:Medicine, Graft vs Host Disease, Disease, Flow cytometry, Young Adult, Immune system, Medicine, Cytotoxic T cell, Humans, Granulocyte Precursor Cells, lcsh:Science, Child, Retrospective Studies, B-Lymphocytes, Peripheral Blood Stem Cell Transplantation, Multidisciplinary, medicine.diagnostic_test, biology, business.industry, lcsh:R, Globulins, Middle Aged, Killer Cells, Natural, surgical procedures, operative, medicine.anatomical_structure, Case-Control Studies, Child, Preschool, Immunology, biology.protein, lcsh:Q, Female, business, Research Article |
| الوصف: | Background Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (PBSCT). However, the precise impact of pre-transplant ATG on immune recovery after PBSCT is still poorly documented. Methods In the current study, we compared immune recovery after myeloablative PBSCT in 65 patients who either received (n = 37) or did not (n = 28) pre-transplant ATG-Fresenius (ATG-F). Detailed phenotypes of circulating T, B, natural killer (NK) and invariant NKT (iNKT) cells were analyzed by multicolor flow cytometry at serial time-points from day 40 to day 365 after transplantation. Thymic function was also assessed by sjTREC quantification. Serious infectious events were collected up to 2 years post-transplantation. Results Pre-transplant ATG-F had a prolonged (for at least up to 1-year) and selective negative impact on the T-cell pool, while it did not impair the recovery of B, NK nor iNKT cells. Among T cells, ATG-F selectively compromised the recovery of naïve CD4+, central memory CD4+ and naïve CD8+ cells, while it spared effector memory T and regulatory T cells. Levels of sjTRECs were similar in both cohorts at 1-year after PBSCT, suggesting that ATG-F unlikely impaired thymopoiesis at long-term after PBSCT. Finally, the incidence and rate of serious infections were similar in both groups, while ATG-F patients had a lower incidence of grade II-IV acute graft-versus-host disease. Conclusions Pre-transplant ATG-F induces long-lasting modulation of the circulating T-cell pool after myeloablative PBSCT, that may participate in preventing graft-versus-host disease without deeply compromising anti-pathogen defenses. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7afecfa48ee053b1a8aca38c10befe3Test http://europepmc.org/articles/PMC4476691Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e7afecfa48ee053b1a8aca38c10befe3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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