التفاصيل البيبلوغرافية
| العنوان: |
Radiologically Isolated Syndrome: 5-Year Risk for an Initial Clinical Event. |
| المؤلفون: |
Okuda, Darin T., Siva, Aksel, Kantarci, Orhun, Inglese, Matilde, Katz, Ilana, Tutuncu, Melih, Keegan, B. Mark, Donlon, Stacy, Hua, Le H., Vidal-Jordana, Angela, Montalban, Xavier, Rovira, Alex, Tintoré, Mar, Amato, Maria Pia, Brochet, Bruno, de Seze, Jérôme, Brassat, David, Vermersch, Patrick, De Stefano, Nicola, Sormani, Maria Pia |
| المصدر: |
PLoS ONE; Mar2014, Vol. 9 Issue 3, p1-9, 9p |
| مصطلحات موضوعية: |
MEDICAL radiology, MEDICAL databases, MULTIVARIATE analysis, MAGNETIC resonance imaging of the brain, NEUROSCIENCES, AUTOIMMUNE diseases, SPINAL cord |
| مستخلص: |
Objective: To report the 5-year risk and to identify risk factors for the development of a seminal acute or progressive clinical event in a multi-national cohort of asymptomatic subjects meeting 2009 RIS Criteria. Methods: Retrospectively identified RIS subjects from 22 databases within 5 countries were evaluated. Time to the first clinical event related to demyelination (acute or 12-month progression of neurological deficits) was compared across different groups by univariate and multivariate analyses utilizing a Cox regression model. Results: Data were available in 451 RIS subjects (F: 354 (78.5%)). The mean age at from the time of the first brain MRI revealing anomalies suggestive of MS was 37.2 years (y) (median: 37.1 y, range: 11–74 y) with mean clinical follow-up time of 4.4 y (median: 2.8 y, range: 0.01–21.1 y). Clinical events were identified in 34% (standard error = 3%) of individuals within a 5-year period from the first brain MRI study. Of those who developed symptoms, 9.6% fulfilled criteria for primary progressive MS. In the multivariate model, age [hazard ratio (HR): 0.98 (95% CI: 0.96–0.99); p = 0.03], sex (male) [HR: 1.93 (1.24–2.99); p = 0.004], and lesions within the cervical or thoracic spinal cord [HR: 3.08 (2.06–4.62); p = <0.001] were identified as significant predictors for the development of a first clinical event. Interpretation: These data provide supportive evidence that a meaningful number of RIS subjects evolve to a first clinical symptom. An age <37 y, male sex, and spinal cord involvement appear to be the most important independent predictors of symptom onset. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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