The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine
| العنوان: | The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine |
|---|---|
| المؤلفون: | Francis Loth, Bryn A. Martin, Theresia I. Yiallourou, Alexander C. Bunck, Mark Goodin, Soroush Heidari Pahlavian, Mehrdad Raisee, R. Shane Tubbs |
| المصدر: | PLoS ONE, Vol 9, Iss 4, p e91888 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science |
| مصطلحات موضوعية: | Male, Physiology, lcsh:Medicine, 02 engineering and technology, Nervous System, Mechanical Treatment of Specimens, 0302 clinical medicine, Cerebrospinal fluid, Biomimetics, Medicine and Health Sciences, Biomechanics, Denticulate ligaments, Nerve Tissue, lcsh:Science, Cerebrospinal Fluid, Foramen magnum, Multidisciplinary, Physics, Classical Mechanics, Anatomy, Magnetic Resonance Imaging, Body Fluids, Arnold-Chiari Malformation, medicine.anatomical_structure, Electroporation, Spinal Cord, Neurology, Specimen Disruption, Physical Sciences, Engineering and Technology, Subarachnoid space, Spinal Nerve Roots, Syringomyelia, Research Article, Biotechnology, Nervous System Physiology, Nerve root, 0206 medical engineering, Biomedical Engineering, Bioengineering, Neuroimaging, Fluid Mechanics, Research and Analysis Methods, Continuum Mechanics, Spinal Cord Diseases, Subarachnoid Space, 03 medical and health sciences, medicine, Humans, Ligaments, business.industry, lcsh:R, Biology and Life Sciences, Cervical Cord, medicine.disease, Spinal cord, 020601 biomedical engineering, SSS, Radiography, Neuroanatomy, Biological Tissue, Specimen Preparation and Treatment, lcsh:Q, Fluid Physiology, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine anatomical structures, including nerve roots and denticulate ligaments (NRDL), have on SSS CSF dynamics is not clear. In the present study we assessed the impact of NRDL on CSF dynamics in the cervical SSS. The 3D geometry of the cervical SSS was reconstructed based on manual segmentation of MRI images of a healthy volunteer and a patient with CM. Idealized NRDL were designed and added to each of the geometries based on in vivo measurments in the literature and confirmation by a neuroanatomist. CFD simulations were performed for the healthy and patient case with and without NRDL included. Our results showed that the NRDL had an important impact on CSF dynamics in terms of velocity field and flow patterns. However, pressure distribution was not altered greatly although the NRDL cases required a larger pressure gradient to maintain the same flow. Also, the NRDL did not alter CSF dynamics to a great degree in the SSS from the foramen magnum to the C1 level for the healthy subject and CM patient with mild tonsillar herniation (similar to 6 mm). Overall, the NRDL increased fluid mixing phenomena and resulted in a more complex flow field. Comparison of the streamlines of CSF flow revealed that the presence of NRDL lead to the formation of vortical structures and remarkably increased the local mixing of the CSF throughout the SSS. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e71a6d368991ca99377c2a10644a43cTest https://infoscience.epfl.ch/record/198885Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e71a6d368991ca99377c2a10644a43c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |