High prevalence of tuberculosis and serious bloodstream infections in ambulatory individuals presenting for antiretroviral therapy in Malawi
| العنوان: | High prevalence of tuberculosis and serious bloodstream infections in ambulatory individuals presenting for antiretroviral therapy in Malawi |
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| المؤلفون: | Anthony D. Harries, Rony Zachariah, Elizabeth L. Corbett, Adrienne K. Chan, Moses Kumwenda, Andrew Ramsay, Monique van Lettow, Ann Åkesson, Robert S. Heyderman, Richard Bedell, Suzanne T. Anderson |
| المصدر: | PLoS ONE, Vol 7, Iss 6, p e39347 (2012) PLoS ONE |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Bacterial Diseases, Malawi, HIV opportunistic infections, lcsh:Medicine, HIV Infections, Bacteremia, Comorbidity, 0302 clinical medicine, Salmonella, Antiretroviral Therapy, Highly Active, Prevalence, Blood culture, Prospective Studies, 030212 general & internal medicine, lcsh:Science, Prospective cohort study, Multidisciplinary, medicine.diagnostic_test, Fungal Diseases, Cryptococcosis, Middle Aged, 3. Good health, Diarrhea, Salmonella Infections, Cohort, Medicine, Infectious diseases, Female, HIV clinical manifestations, medicine.symptom, Infection, ART, Research Article, Cohort study, Adult, medicine.medical_specialty, Tuberculosis, Anemia, 030231 tropical medicine, Viral diseases, 03 medical and health sciences, Internal medicine, medicine, Humans, AIDS-Related Opportunistic Infections, business.industry, lcsh:R, Sputum, Tropical Diseases (Non-Neglected), HIV, Bloodstream Infections, medicine.disease, Immunology, lcsh:Q, business |
| الوصف: | BACKGROUND: Tuberculosis (TB) and serious bloodstream infections (BSI) may contribute to the high early mortality observed among patients qualifying for antiretroviral therapy (ART) with unexplained weight loss, chronic fever or chronic diarrhea. METHODS AND FINDINGS: A prospective cohort study determined the prevalence of undiagnosed TB or BSI among ambulatory HIV-infected adults with unexplained weight loss and/or chronic fever, or diarrhea in two routine program settings in Malawi. Subjects with positive expectorated sputum smears for AFB were excluded. Investigations Bacterial and mycobacterial blood cultures, cryptococcal antigen test (CrAg), induced sputum (IS) for TB microscopy and solid culture, full blood count and CD4 lymphocyte count. Among 469 subjects, 52 (11%) had microbiological evidence of TB; 50 (11%) had a positive (non-TB) blood culture and/or positive CrAg. Sixty-five additional TB cases were diagnosed on clinical and radiological grounds. Nontyphoidal Salmonellae (NTS) were the most common blood culture pathogens (29 cases; 6% of participants and 52% of bloodstream isolates). Multivariate analysis of baseline clinical and hematological characteristics found significant independent associations between oral candidiasis or lymphadenopathy and TB, marked CD4 lymphopenia and NTS infection, and severe anemia and either infection, but low positive likelihood ratios ( |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db47335a1bbe1e136e30f063dcbb8d4Test https://researchonline.lshtm.ac.uk/id/eprint/103770/1/pone.0039347.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7db47335a1bbe1e136e30f063dcbb8d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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