Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women
| العنوان: | Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women |
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| المؤلفون: | Ko Willems van Dijk, Albert de Roos, Theodora W. Elffers, Frits R. Rosendaal, Renée de Mutsert, Stella Trompet, J. Wouter Jukema, Hildo J. Lamb |
| المصدر: | PLoS ONE PLoS ONE, 12(9) PLoS ONE, Vol 12, Iss 9, p e0185403 (2017) |
| بيانات النشر: | Public Library of Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Physiology, lcsh:Medicine, Adipose tissue, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Biochemistry, Diagnostic Radiology, Fats, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Odds Ratio, Medicine, Body Fat Distribution, Public and Occupational Health, lcsh:Science, Metabolic Syndrome, education.field_of_study, Multidisciplinary, Radiology and Imaging, Middle Aged, Lipids, Magnetic Resonance Imaging, Adipose Tissue, Physiological Parameters, Cardiovascular Diseases, Female, Anatomy, Research Article, medicine.medical_specialty, Waist, Imaging Techniques, Population, 030209 endocrinology & metabolism, Intra-Abdominal Fat, Research and Analysis Methods, 03 medical and health sciences, Classification of obesity, Diagnostic Medicine, Internal medicine, Cardiovascular Diseases in Women, Humans, Obesity, Risk factor, education, Aged, business.industry, lcsh:R, Body Weight, nutritional and metabolic diseases, Biology and Life Sciences, Health Risk Analysis, Odds ratio, Physical Activity, medicine.disease, Health Care, Endocrinology, Biological Tissue, Epidemiology of obesity, Women's Health, lcsh:Q, business |
| الوصف: | Background Body fat distribution is, next to overall obesity, an important risk factor for cardiometabolic outcomes in the general population. In particular, visceral adipose tissue (VAT) is strongly associated with cardiometabolic risk factors. Since it is unclear whether body fat distribution is also important in men and women with obesity we investigated the associations between measures of body fat distribution and cardiometabolic risk factors in men and women with obesity. Methods In this cross-sectional analysis of obese men and women (BMI≥30 kg/m2) included in the Netherlands Epidemiology of Obesity Study, waist:hip ratio(WHR), waist circumference, and MRI-based abdominal subcutaneous adipose tissue (aSAT) and VAT were determined. Associations between measures of body fat distribution and presence of ≥1 risk factor, such as hypertension or hypertriglyceridemia, were examined using logistic regression analyses; stratified by sex and adjusted for age, ethnicity, education, tobacco smoking, alcohol consumption, physical activity and depending on the association additionally for total body fat or VAT. Results We included 2,983 obese individuals (57% women) with a mean age of 56 and standard deviation (SD) of 6 and mean BMI of 34.0 kg/m2 (4.0), after exclusion of individuals with missing values of cardiometabolic risk factors (n = 33). 241 individuals were obese without other cardiometabolic risk factors. In obese women, all measures of body fat distribution except aSAT (OR per SD:0.76, 95%CI: 0.53, 1.10) were associated with having ≥1 cardiometabolic risk factor, of which VAT most strongly associated (5.77; 3.02, 11.01). In obese men, associations of body fat distribution and the presence of cardiometabolic risk factors were attenuated. (e.g. VAT:1.42; 0.84, 2.41). Conclusions In obese women, but less so in men, measures of body fat distribution, of which VAT most strongly, are associated with cardiometabolic risk factors. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb94e3858bd82f3c5d2dacc039288606Test http://europepmc.org/articles/PMC5619737Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb94e3858bd82f3c5d2dacc039288606 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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