دورية أكاديمية
Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake
| العنوان: | Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake |
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| المؤلفون: | Christensen, Brock C., Kelsey, Karl T., Zheng, Shichun, Marsit, Carmen J., Wrensch, Margaret R., Wiemels, Joseph L., Nelson, Heather H., Karagas, Margaret R., Kushi, Lawrence H., Kwan, Marilyn L., Wiencke, John K., Horwitz, Marshall S., Houseman, Eugene Andres |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2010 |
| المجموعة: | Harvard University: DASH - Digital Access to Scholarship at Harvard |
| مصطلحات موضوعية: | public health and epidemiology, environmental health, oncology, breast cancer, genetics and genomics, epigenetics, cancer genetics |
| الوصف: | Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors from 162 (AJCC stage I–IV) women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpG loci associated with 773 cancer-related genes and validated select CpG loci with Sequenom EpiTYPER. Tumor grade, size, estrogen and progesterone receptor status, and triple negative status were significantly (Q-values <0.05) associated with altered methylation of 209, 74, 183, 69, and 130 loci, respectively. Unsupervised clustering, using a recursively partitioned mixture model (RPMM), of all autosomal CpG loci revealed eight distinct methylation classes. Methylation class membership was significantly associated with patient race (P<0.02) and tumor size (P<0.001) in univariate tests. Using multinomial logistic regression to adjust for potential confounders, patient age and tumor size, as well as known disease risk factors of alcohol intake and total dietary folate, were all significantly (P<0.0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns. ; Version of Record |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1553-7390 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912395/pdfTest/; PLoS Genetics; Christensen, Brock C., Karl T. Kelsey, Shichun Zheng, E. Andres Houseman, Carmen J. Marsit, Margaret R. Wrensch, Joseph L. Wiemels, et al. 2010. Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genetics 6(7): e1001043; http://nrs.harvard.edu/urn-3:HUL.InstRepos:4555852Test |
| DOI: | 10.1371/journal.pgen.1001043 |
| الإتاحة: | https://doi.org/10.1371/journal.pgen.1001043Test http://nrs.harvard.edu/urn-3:HUL.InstRepos:4555852Test |
| رقم الانضمام: | edsbas.101B9F2E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15537390 |
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| DOI: | 10.1371/journal.pgen.1001043 |