Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model
| العنوان: | Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model |
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| المؤلفون: | John H. Zhang, Li Li, Junjia Tang, Jiping Tang, Desislava Doycheva, Margaret Barnhart, Pradilka N. Drunalini Perera, Qin Hu |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 2, p e90258 (2014) |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | lcsh:Medicine, Developmental and Pediatric Neurology, Cardiovascular, Pediatrics, Rats, Sprague-Dawley, Behavioral Neuroscience, Weight loss, Medicine, Hippocampus (mythology), lcsh:Science, Ischemic Postconditioning, Sensory motor, Multidisciplinary, Brain, Animal Models, Organ Size, 3. Good health, Hindlimb, Cerebellar Disorders, Neurology, Anesthesia, Hypoxia-Ischemia, Brain, medicine.symptom, Research Article, Cerebrovascular Diseases, Rat model, Ischemia, Brain damage, Motor Activity, Atrophy, Model Organisms, Vascular Biology, Transient Ischemic Attacks, Animals, Maze Learning, Biology, Ischemic Stroke, Hypoxic ischemic, business.industry, lcsh:R, Recovery of Function, medicine.disease, Rats, Disease Models, Animal, Animals, Newborn, Rat, lcsh:Q, business, Neuroscience |
| الوصف: | Objective Remote Ischemic Postconditioning (RIPC) is a promising therapeutic intervention wherein a sub-lethal ischemic insult induced in one organ (limb) improves ischemia in an organ distant to it (brain). The main objective of this study was to investigate the long-term functional effects of delayed RIPC in a neonatal hypoxia-ischemia (HI) rat model. Method 10 day old rat pups were subjected to delayed RIPC treatment and randomized into four groups: 1) Sham, 2) HI induced, 3) HI +24 hr delayed RIPC, and 4) HI +24 hr delayed RIPC with three consecutive daily treatments. Neurobehavioral tests, brain weights, gross and microscopic brain tissue morphologies, and systemic organ weights were evaluated at five weeks post surgery. Results HI induced rats performed significantly worse than sham but both groups of delayed RIPC treatment showed improvement of sensory motor functions. Furthermore, compared to the HI induced group, the delayed RIPC treatment groups showed no further detrimental changes on brain tissue, both grossly and morphologically, and no changes on the systemic organ weights. Conclusion Delayed RIPC significantly improves long term sensory motor deficits in a neonatal HI rat model. A 24 hr delayed treatment does not significantly attenuate morphological brain injury but does attenuate sensory motor deficits. Sensory motor deficits improve with both a single treatment and with three consecutive daily treatments, and the consecutive treatments are possibly being more beneficial. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf55d66a0866a2cfe0590cfae4683bTest http://europepmc.org/articles/PMC3938659Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....babf55d66a0866a2cfe0590cfae4683b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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