Lactate Dehydrogenase 5 Expression in Non-Hodgkin Lymphoma Is Associated with the Induced Hypoxia Regulated Protein and Poor Prognosis
| العنوان: | Lactate Dehydrogenase 5 Expression in Non-Hodgkin Lymphoma Is Associated with the Induced Hypoxia Regulated Protein and Poor Prognosis |
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| المؤلفون: | Xinmin Zhao, Zhujun Chen, Lin Guo, Hongfeng Hu, Xiaofeng Xu, Minglei Jiang, Xiang Gao, Renquan Lu |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 9, p e74853 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pathology, Adolescent, lcsh:Medicine, Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, chemistry.chemical_compound, Young Adult, immune system diseases, Internal medicine, Lactate dehydrogenase, hemic and lymphatic diseases, medicine, Humans, lcsh:Science, Aged, Proportional Hazards Models, Aged, 80 and over, Multidisciplinary, Performance status, Tumor hypoxia, L-Lactate Dehydrogenase, business.industry, Proportional hazards model, Lymphoma, Non-Hodgkin, lcsh:R, Case-control study, Hypoxia (medical), Middle Aged, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, Lymphoma, Isoenzymes, chemistry, Case-Control Studies, Multivariate Analysis, lcsh:Q, Female, medicine.symptom, Lactate Dehydrogenase 5, business, Research Article |
| الوصف: | Lactate dehydrogenase 5 (LDH-5) is one of the major isoenzymes catalyzing the biochemical process of pyruvate to lactate. The purpose of this study was to investigate the expression of serum LDH-5 and test whether this enzyme is regulated by tumor hypoxia and represents a prognostic marker in patients with Non-Hodgkin's lymphoma (NHL). In this study, LDH-5 levels were detected using agarose gel electrophoresis in NHL patients (n = 266) and non-NHL controls including benign lymphadenectasis (n = 30) and healthy cohorts (n = 233). We also explored the expression of LDH-5 and hypoxia-inducible factor (HIF) 1α in NHL and benign controls by immunohistochemistry and immunofluorescence staining, respectively. Moreover, the role of LDH-5 in the progression of NHL was assessed by multivariate Cox analyses and Kaplan-Meier survival estimates. Serum concentrations of LDH-5 were significantly higher in NHL patients (9.3%) than in benign patients and healthy controls (7.5% and 7.2%, respectively, P |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1e0486767e1a4a28cf34b9e2dc9133Test http://europepmc.org/articles/PMC3781153Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f1e0486767e1a4a28cf34b9e2dc9133 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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