دورية أكاديمية
Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment: A Randomized Clinical Trial.
| العنوان: | Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment: A Randomized Clinical Trial. |
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| المؤلفون: | Nogueira, Raul G, Lobsien, Donald, Klisch, Joachim, Pielenz, Daniel, Lobsien, Elmar, Sauvageau, Eric, Aghaebrahim, Nima, Möhlenbruch, Markus, Vollherbst, Dominik, Ulfert, Christian, Bozorgchami, Hormozd, Clark, Wayne, Priest, Ryan, Samaniego, Edgar A, Ortega-Gutierrez, Santiago, Ghannam, Malik, Lopes, Demetrius, Billingsley, Joshua, Keigher, Kiffon, Haussen, Diogo C, Al-Bayati, Alhamza R, Siddiqui, Adnan, Levy, Elad, Chen, Michael, Munich, Stephan, Schramm, Peter, Boppel, Tobias, Narayanan, Sandra, Gross, Bradley A, Roth, Christian, Boeckh-Behrens, Tobias, Hassan, Ameer, Fifi, Johanna, Budzik, Ron F, Tarpley, Jason, Starke, Robert M, Raz, Eytan, Brogan, Gary, Liebeskind, David S, Hanel, Ricardo A |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence Digital Commons |
| سنة النشر: | 2024 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | Aged, 80 and over, Female, Humans, Male, Brain Ischemia, Cerebral Infarction, Ischemic Stroke, Prospective Studies, Stents, Stroke, Thrombectomy, Treatment Outcome, Middle Aged, california, plcmmc, torrance, pni, Neurology, Neurosurgery, Surgery |
| الوصف: | IMPORTANCE: Stent retriever-based thrombectomy is highly beneficial in large vessel occlusion (LVO) strokes. Many stent retriever designs are currently available, but comparison of these technologies in well-conducted studies is lacking. OBJECTIVE: To determine whether thrombectomy for LVO stroke with the pRESET stent retriever is noninferior to treatment with the Solitaire stent retriever. DESIGN, SETTING, AND PARTICIPANTS: This study was a multicenter, prospective, randomized, controlled, open-label, adaptive, noninferiority trial with blinded primary end point evaluation. Between October 2019 and February 2022, multicenter participation occurred across 19 research hospitals and/or universities in the US and 5 in Germany. Patients with LVO stroke were enrolled and included up to 8 hours after symptom onset. INTERVENTIONS: Patients underwent 1:1 randomization to thrombectomy with the pRESET or Solitaire stent retriever. MAIN OUTCOMES AND MEASURES: The primary outcome was the difference in the rate of 90-day functional independence across the 2 devices, using a -12.5% noninferiority margin for the lower bound of the 1-sided 95% CI of the difference between pRESET and Solitaire retrievers. RESULTS: Of 340 randomized patients, 170 (50.0%) were female, and the median (IQR) age was 73.0 (64.0-82.0) years. The study procedure was completed in 322 of the 340 randomized patients. The primary end point of 90-day functional independence was achieved by 95 patients (54.9%; 95% CI, 48.7-61.1) in the pRESET group and in 96 (57.5%; 95% CI, 51.2-63.8) in the Solitaire group (absolute difference, -2.57%; 95% CI, -11.42 to 6.28). As the lower bound of the 95% CI was greater than -12.5%, the pRESET retriever was deemed noninferior to the Solitaire retriever. The noninferiority of pRESET over Solitaire was also observed in the secondary clinical end point (90-day shift in modified Rankin Scale score) and in both angiographic end points (Expanded Treatment in Cerebral Infarction [eTICI] score of 2b50 or greater within 3 passes: ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.providence.org/publications/8489Test; https://pubmed.ncbi.nlm.nih.gov/38165690Test/ |
| الإتاحة: | https://digitalcommons.providence.org/publications/8489Test https://pubmed.ncbi.nlm.nih.gov/38165690Test/ |
| رقم الانضمام: | edsbas.F0F19CE3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |