Antibody-producing cells: virus-induced alteration of response to antigen
| العنوان: | Antibody-producing cells: virus-induced alteration of response to antigen |
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| المؤلفون: | Vernon Riley, Werner Braun, Darrel H. Spackman, Masaaki Ishizuka |
| المصدر: | Proceedings of the National Academy of Sciences. 73:1707-1711 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1976. |
| سنة النشر: | 1976 |
| مصطلحات موضوعية: | Asparaginase, Lactate dehydrogenase-elevating virus, Spleen, Viremia, Stimulation, Biology, Virus, Mice, chemistry.chemical_compound, Antigen, Antibody Specificity, medicine, Animals, RNA Viruses, Antibody-Producing Cells, B-Lymphocytes, Leukemia, Experimental, Multidisciplinary, Organ Size, biology.organism_classification, medicine.disease, Molecular biology, Leukemia, medicine.anatomical_structure, chemistry, Acute Disease, Antibody Formation, Chronic Disease, Immunology, Female, Lactate dehydrogenase elevating virus, Research Article |
| الوصف: | Spleen antibody-forming cells of mice yield a 3- to 10-fold increase in their response to sheep erythrocyte antigen if they are acutely infected by lactate dehydrogenase-elevating virus. This early stimulation is replaced by a long-term inhibition of the antibody-forming cells as the viremia goes into its persisting chronic stage. These contrasting immunological phenomena are examined as contributing factors responsible for the enhancement by this virus of asparaginase (EC 3.5.1.1; L-asparagine amidolydrolase) therapy against leukemia in mice, and for the alteration of the susceptibility of mice to various neoplastic processes. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcf2238893a59158e393e73889c7b84Test https://doi.org/10.1073/pnas.73.5.1707Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....abcf2238893a59158e393e73889c7b84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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