Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin
| العنوان: | Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin |
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| المؤلفون: | Vivian L. Braciale, Marianne T. Sweetser, T J Braciale, Lynda A. Morrison, David J. Kittlesen |
| المصدر: | Proceedings of the National Academy of Sciences. 86:277-281 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, Genes, Viral, Molecular Sequence Data, Orthomyxoviridae, Genes, MHC Class I, Hemagglutinins, Viral, Hemagglutinin (influenza), Hemagglutinin Glycoproteins, Influenza Virus, chemical and pharmacologic phenomena, Immunodominance, medicine.disease_cause, Major histocompatibility complex, Epitope, Cell Line, Epitopes, Mice, MHC class I, Influenza A virus, medicine, Animals, Amino Acid Sequence, Cloning, Molecular, Immunity, Cellular, Mice, Inbred BALB C, Multidisciplinary, biology, biology.organism_classification, Virology, Influenza B virus, CTL, Genes, Mice, Inbred CBA, biology.protein, Chromosome Deletion, T-Lymphocytes, Cytotoxic, Research Article |
| الوصف: | Two distinct regions of the influenza A/JAP/305/57 hemagglutinin molecule are identifiable as sites recognized by murine class I major histocompatibility complex (MHC) (H-2d)-restricted cytolytic T lymphocytes (CTL) generated in response to immunization with infectious type A influenza virus. Each of these sites can be mimicked by a synthetic oligopeptide of approximately 20 amino acids. Data presented herein indicate that these two sites define the dominant immunogenic epitopes on the hemagglutinin recognized by H-2Kd-restricted CTL. These same sites are not efficiently recognized by hemagglutinin-specific class I MHC-restricted CTL of several unrelated MHC haplotypes. These observations show that even for a large complex glycoprotein molecule like the influenza hemagglutinin, only a limited number of class I CTL recognition sites are generated in the infected cell and that the subset of immunogenic epitopes is dependent on the MHC haplotype of the responding individual. These parameters need to be considered in the design of synthetic and recombinant vaccines. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93388e415476bf7d53a0061c029368d7Test https://doi.org/10.1073/pnas.86.1.277Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....93388e415476bf7d53a0061c029368d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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