Identification and preliminary characterization of a protein motif related to the zinc finger
| العنوان: | Identification and preliminary characterization of a protein motif related to the zinc finger |
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| المؤلفون: | Dinah Rahman, Paul S. Freemont, John Trowsdale, Nicola O’Reilly, Darryl J. Pappin, Gerard I. Evan, Ruth C. Lovering, Isabel M. Hanson, Katherine L. B. Borden, Stephen R. Martin |
| المصدر: | Proceedings of the National Academy of Sciences. 90:2112-2116 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Molecular Sequence Data, Biology, Protein Structure, Secondary, Cell Line, Kelch motif, Tumor Cells, Cultured, Ring finger, medicine, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Structural motif, Polycomb Repressive Complex 1, Genetics, Zinc finger, Multidisciplinary, Base Sequence, Sequence Homology, Amino Acid, Zinc Fingers, Cobalt, DNA, Oncogenes, DNA-Binding Proteins, RING finger domain, Zinc, Tetratricopeptide, medicine.anatomical_structure, Spectrophotometry, PHD finger, RNA, Poly A, Sequence motif, HeLa Cells, Protein Binding, Research Article |
| الوصف: | We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six. We propose naming this motif the "RING finger" and it is found in 27 proteins, all of which have putative DNA binding functions. We have synthesized a peptide corresponding to the RING1 motif and examined a number of properties, including metal and DNA binding. We provide evidence to support the suggestion that the RING finger motif is the DNA binding domain of this newly defined family of proteins. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d545f722710b9be09bd2490146f702d0Test https://doi.org/10.1073/pnas.90.6.2112Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d545f722710b9be09bd2490146f702d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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