Human placental trophoblasts confer viral resistance to recipient cells
| العنوان: | Human placental trophoblasts confer viral resistance to recipient cells |
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| المؤلفون: | Yoel Sadovsky, Tianjiao Chu, Adrian E. Morelli, Carolyn B. Coyne, Elizabeth Delorme-Axford, Yingshi Ouyang, Avraham Bayer, Donna B. Stolz, Jean-Francois Mouillet, Rogier B. Donker, Saumendra N. Sarkar, Tianyi Wang |
| المصدر: | Proceedings of the National Academy of Sciences. 110:12048-12053 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Placenta, Green Fluorescent Proteins, Enzyme-Linked Immunosorbent Assay, Biology, Exosomes, Paracrine signalling, Pregnancy, Immunity, microRNA, Autophagy, medicine, Humans, Cells, Cultured, Disease Resistance, Analysis of Variance, Multidisciplinary, Effector, Biological Sciences, Virology, Microvesicles, Trophoblasts, Cell biology, MicroRNAs, medicine.anatomical_structure, Viral replication, Virus Diseases, embryonic structures, Female, Chromosomes, Human, Pair 19 |
| الوصف: | Placental trophoblasts form the interface between the fetal and maternal environments and serve to limit the maternal–fetal spread of viruses. Here we show that cultured primary human placental trophoblasts are highly resistant to infection by a number of viruses and, importantly, confer this resistance to nonplacental recipient cells by exosome-mediated delivery of specific microRNAs (miRNAs). We show that miRNA members of the chromosome 19 miRNA cluster, which are almost exclusively expressed in the human placenta, are packaged within trophoblast-derived exosomes and attenuate viral replication in recipient cells by the induction of autophagy. Together, our findings identify an unprecedented paracrine and/or systemic function of placental trophoblasts that uses exosome-mediated transfer of a unique set of placental-specific effector miRNAs to directly communicate with placental or maternal target cells and regulate their immunity to viral infections. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac339ea8137358db5448e99e5f6bd6dTest https://doi.org/10.1073/pnas.1304718110Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0ac339ea8137358db5448e99e5f6bd6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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