Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy
| العنوان: | Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy |
|---|---|
| المؤلفون: | Enrica Chiti, Giovanni Donato Aquaro, Marco Di Paolo, Matteo Scopetti, Federico Biondi, Benedetta Guidi, Emanuela Turillazzi, Alessandro Santurro |
| المصدر: | Diagnostics, Vol 10, Iss 981, p 981 (2020) Diagnostics Volume 10 Issue 11 |
| بيانات النشر: | Preprints, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Clinical Biochemistry, Diastole, sudden death, macromolecular substances, 030204 cardiovascular system & hematology, Sudden death, Article, Muscle hypertrophy, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, post-mortem cardiac magnetic resonance, Internal medicine, medicine, 030212 general & internal medicine, cardiovascular diseases, Rigor mortis, lcsh:R5-920, business.industry, allergology, Hypertrophic cardiomyopathy, medicine.disease, hypertrophic cardiomyopathy, Cardiology, cardiovascular system, business, Cardiac magnetic resonance, lcsh:Medicine (General), Post-mortem cardiac magnetic resonance, Cardiac phase |
| الوصف: | Background: Post-mortem cardiac magnetic resonance (PMCMR) is an emerging tool supporting forensic medicine for the identification of the causes of cardiac death, such as hypertrophic cardiomyopathy (HCM). We proposed a new method of PMCMR to diagnose HCM despite myocardial rigor mortis. Methods: We performed CMR in 49 HCM patients, 30 non-HCM hypertrophy, and 32 healthy controls. In cine images, rigor mortis was simulated by the analysis of the cardiac phase corresponding to 25% of diastole. Left ventricular mass, mean, and standard deviation (SD) of WT, maximal WT, minimal WT, and their difference were compared for the identification of HCM. These parameters were validated at PMCMR, evaluating eight hearts with HCM, 10 with coronary artery disease, and 10 with non-cardiac death. Results: The SD of WT with a cut-off of > 2.4 had the highest accuracy to identify HCM (AUC 0.95, 95% CI = 0.89&ndash 0.98). This was particularly evident in the female population of HCM (AUC=0.998), with 100% specificity (95% CI = 85&ndash 100%) and 96% sensitivity (95% CI = 79&ndash 99%). Using this parameter, at PMCMR, all of the eight patients with HCM were correctly identified with no false positives. Conclusions: PMCMR allows identification of HCM as the cause of sudden death using the SD of WT > 2.4 as the diagnostic parameter. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62318d762cf9c2df5c294fadbc021456Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....62318d762cf9c2df5c294fadbc021456 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |