High-Sensitivity Detection of IgG Operating Near the Dispersion Turning Point in Tapered Two-Mode Fibers
| العنوان: | High-Sensitivity Detection of IgG Operating Near the Dispersion Turning Point in Tapered Two-Mode Fibers |
|---|---|
| المؤلفون: | Bing Sun, Yiping Wang |
| المصدر: | Micromachines Volume 11 Issue 3 Micromachines, Vol 11, Iss 3, p 270 (2020) |
| بيانات النشر: | Preprints, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | two-mode fiber, Materials science, lcsh:Mechanical engineering and machinery, optical fiber sensor, biosensor, 01 natural sciences, Article, 010309 optics, control_systems_engineering, 0103 physical sciences, Dispersion (optics), Miniaturization, lcsh:TJ1-1570, Turning point, Electrical and Electronic Engineering, Detection limit, business.industry, Mechanical Engineering, 010401 analytical chemistry, Response time, sensitivity, 0104 chemical sciences, Control and Systems Engineering, Fiber optic sensor, Optoelectronics, business, Biosensor, Sensitivity (electronics) |
| الوصف: | The conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing was investigated by the implementation of antibody/antigen immunoassays. The ultrasensitive detection of IgG levels could be achieved by exploiting the dispersion turning point (DTP) existing in the tapered two-mode fibers (TTMFs) because the sensitivity will reach ± &infin on either side of the DTP. Tracking the resonant wavelength shift, it was found that the fabricated TTMF device exhibited limits of detection (LOD) down to concentrations of 10 fg/mL of IgG in PBS solution. Such immunosensors based on DTP have great significance on trace detection of IgG due to simple detection scheme, quick response time, and miniaturization. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9feb7fabd38c5546e9d380950ca046Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af9feb7fabd38c5546e9d380950ca046 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |