Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice

التفاصيل البيبلوغرافية
العنوان:	Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice
المؤلفون:	Hang, Bo, Wang, Yunshan, Huang, Yurong, Wang, Pin, Langley, Sasha A., Bi, Lei, Sarker, Altaf H., Schick, Suzaynn F., Havel, Christopher, Jacob, Peyton, Benowitz, Neal, Destaillats, Hugo, Tang, Xiaochen, Xia, Yankai, Jen, Kuang-Yu, Gundel, Lara A., Mao, Jian-Hua, Snijders, Antoine M.
المصدر:	Clinical Science ; volume 132, issue 4, page 475-488 ; ISSN 0143-5221 1470-8736
بيانات النشر:	Portland Press Ltd.
سنة النشر:	2018
الوصف:	Exposure to thirdhand smoke (THS) is a recently described health concern that arises in many indoor environments. However, the carcinogenic potential of THS, a critical consideration in risk assessment, remains untested. Here we investigated the effects of short-term early exposure to THS on lung carcinogenesis in A/J mice. Forty weeks after THS exposure from 4 to 7 weeks of age, the mice had increased incidence of lung adenocarcinoma, tumor size and, multiplicity, compared with controls. In vitro studies using cultured human lung cancer cells showed that THS exposure induced DNA double-strand breaks and increased cell proliferation and colony formation. RNA sequencing analysis revealed that THS exposure induced endoplasmic reticulum stress and activated p53 signaling. Activation of the p53 pathway was confirmed by an increase in its targets p21 and BAX. These data indicate that early exposure to THS is associated with increased lung cancer risk.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1042/cs20171521
الإتاحة:	https://doi.org/10.1042/cs20171521Test https://portlandpress.com/clinsci/article-pdf/132/4/475/446319/cs-2017-1521.pdfTest
حقوق:	https://creativecommons.org/licenses/by-nc-nd/4.0Test/
رقم الانضمام:	edsbas.46BB322E
قاعدة البيانات:	BASE

View record in BASE

الوصف
DOI:	10.1042/cs20171521